Now showing items 1-13 of 13

    • Chromhome: A rich internet application for accessing comparative chromosome homology maps 

      Nagarajan, Sridevi; Rens, Willem; Stalker, James; Cox, Tony; Ferguson-Smith, Malcolm (2008-03-26)
      Abstract Background Comparative genomics has become a significant research area in recent years, following the availability of a number of sequenced genomes. The comparison of genomes is of great importance in the analysis ...
    • Comparative analysis of sex chromosomes in Leporinus species (Teleostei, Characiformes) using chromosome painting 

      Parise-Maltempi, Patrícia P; da, Silva Edson L; Rens, Willem; Dearden, Frances; O’Brien, Patricia CM; Trifonov, Vladimir; Ferguson-Smith, Malcolm (2013-07-03)
      Abstract Background The Leporinus genus, belonging to the Anostomidae family, is an interesting model for studies of sex chromosome evolution in fish, particularly because of the presence of heteromorphic sex chromosomes ...
    • Contrasting origin of B chromosomes in two cervids (Siberian roe deer and grey brocket deer) unravelled by chromosome-specific DNA sequencing 

      Makunin, Alexey I; Kichigin, Ilya G; Larkin, Denis M; O’Brien, Patricia CM; Ferguson-Smith, Malcolm; Yang, Fengtang; Proskuryakova, Anastasiya A et al. (2016-08-11)
      Abstract Background B chromosomes are dispensable and variable karyotypic elements found in some species of animals, plants and fungi. They often originate from duplications ...
    • Disruption of chromosome 11 in canine fibrosarcomas highlights an unusual variability of CDKN2B in dogs. 

      Aguirre-Hernandez, Jesus; Milne, Bruce S; Queen, Chris; O'Brien, Patricia CM; Hoather, Tess; Haugland, Sean; Ferguson-Smith, Malcolm et al. (2009-07-31)
      Abstract Background In dogs in the western world neoplasia constitutes the most frequently diagnosed cause of death. Although there appear to be similarities between canine and human cancers, rather little is known about ...
    • The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals 

      Edwards, Carol Ann; Rens, Willem; Clark, Oliver; Mungall, Andrew J; Hore, Timothy; Marshall, Graves Jennifer A; Dunham, Ian et al. (2007-09-06)
      Abstract Background The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the ...
    • Extensive Karyotype Reorganization in the Fish Gymnotus arapaima (Gymnotiformes, Gymnotidae) Highlighted by Zoo-FISH Analysis. 

      Machado, Milla de Andrade; Pieczarka, Julio C; Silva, Fernando HR; O'Brien, Patricia CM; Ferguson-Smith, Malcolm; Nagamachi, Cleusa Y (2018-01-26)
    • Flying lemurs - the "flying tree shrews"? Molecular cytogenetic evidence for a Scandentia-Dermoptera sister clade 

      Nie, Wenhui; Fu, Beiyuan; O'Brien, Patricia CM; Wang, Jinhuan; Su, Weiting; Tanomtong, Alongklod; Volobouev, Vitaly et al. (2008-05-01)
      Abstract Background Flying lemurs or Colugos (order Dermoptera) represent an ancient mammalian lineage that contains only two extant species. Although molecular evidence strongly supports that the orders Dermoptera, ...
    • Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development 

      Renfree, Marilyn B; Papenfuss, Anthony T; Deakin, Janine E; Lindsay, James; Heider, Thomas; Belov, Katherine; Rens, Willem et al. (BioMed Central, 2011-12-30)
      Background. We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be ...
    • Karyotype evolution in birds: From conventional staining to chromosome painting 

      Kretschmer, R; Ferguson-Smith, Malcolm; de Oliveira, EHC (MDPI AG, 2018-04-01)
      In this work we performed comparative chromosome painting using probes from Gallus gallus (GGA) Linnaeus, 1758 and Leucopternis albicollis (LAL) Latham, 1790 in Synallaxis frontalis Pelzeln, 1859 (Passeriformes, Furnariidae), ...
    • Multidirectional chromosome painting substantiates the occurrence of extensive genomic reshuffling within Accipitriformes 

      Nie, Wenhui; O’Brien, Patricia CM; Fu, Beiyuan; Wang, Jinghuan; Su, Weiting; He, Kai; Bed’Hom, Bertrand et al. (2015-09-26)
      Abstract Background Previous cross-species painting studies with probes from chicken (Gallus gallus) chromosomes 1–10 and a paint pool of nineteen microchromosomes have revealed ...
    • Multiple rearrangements in cryptic species of electric knifefish, Gymnotus carapo (Gymnotidae, Gymnotiformes) revealed by chromosome painting 

      Nagamachi, Cleusa Y; Pieczarka, Julio C; Milhomem, Susana SR; O'Brien, Patricia CM; de, Souza Augusto CP; Ferguson-Smith, Malcolm (2010-04-27)
      Abstract Background Gymnotus (Gymnotidae, Gymnotiformes) is the Neotropical electric fish genus with the largest geographic distribution and the largest number of species, 33 of which have been validated. The diploid number ...
    • The multiple sex chromosomes of platypus and echidna are not completely identical and several share homology with the avian Z 

      Rens, Willem; O'Brien, Patricia CM; Grutzner, Frank; Clarke, Oliver; Graphodatskaya, Daria; Tsend-Ayush, Enkhjargal; Trifonov, Vladimir A et al. (2007-11-16)
      Abstract Background Sex-determining systems have evolved independently in vertebrates. Placental mammals and marsupials have an XY system, birds have a ZW system. Reptiles and amphibians have different systems, including ...
    • Targeted deletion of a 170-kb cluster of LINE-1 repeats and implications for regional control. 

      Soares, Miguel L; Edwards, Carol Ann; Dearden, Frances L; Ferrón, Sacri R; Curran, Scott; Corish, Jennifer A; Rancourt, Rebecca C et al. (Cold Spring Harbor Laboratory Press, 2018-01-24)
      Around half of the mammalian genome is composed of repetitive sequences and accumulating evidence suggests that some may have an impact on genome function. Here, we characterised a large array class of repeats of ...