Now showing items 1-4 of 4

    • Enhancer evolution across twenty mammals 

      Villar, Diego; Berthelot, Camille; Aldridge, Sarah; Rayner, Tim F; Lukk, Margus; Pignatelli, Miguel; Park, Thomas J et al. (Elsevier, 2014-12-15)
      The mammalian radiation has corresponded with rapid changes in noncoding regions of the genome, but we lack a comprehensive understanding of regulatory evolution in mammals. Here, we track the evolution of promoters and ...
    • Genome sequence of an Australian kangaroo, Macropus eugenii, provides insight into the evolution of mammalian reproduction and development 

      Renfree, Marilyn B; Papenfuss, Anthony T; Deakin, Janine E; Lindsay, James; Heider, Thomas; Belov, Katherine; Rens, Willem et al. (BioMed Central, 2011-12-30)
      Background. We present the genome sequence of the tammar wallaby, Macropus eugenii, which is a member of the kangaroo family and the first representative of the iconic hopping mammals that symbolize Australia to be ...
    • Interplay of cis and trans mechanisms driving transcription factor binding and gene expression evolution 

      Wong, Emily S; Schmitt, Bianca M; Kazachenka, Anastasiya; Thybert, David; Redmond, Aisling; Connor, Frances; Rayner, Tim F et al. (Springer Nature, 2017-10-23)
      Noncoding regulatory variants play a central role in the genetics of human diseases and in evolution. Here we measure allele-specific transcription factor binding occupancy of three liver-specific transcription factors ...
    • Transcriptional diversity during lineage commitment of human blood progenitors 

      Chen, Lu; Kostadima, Myrto; Martens, Joost HA; Canu, Giovanni; Garcia, Sara P; Turro, Ernest; Downes, Kate et al. (AAAS, 2014-09-26)
      Blood cells derive from hematopoietic stem cells through stepwise fating events. To characterize gene expression programs driving lineage choice we sequenced RNA from eight primary human hematopoietic progenitor populations ...