Now showing items 1-15 of 15

    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A; Johnson, Laura; Franco, Oscar H et al. (American College of Physicians, 2014-03-18)
      Background: Guidelines advocate changes in fatty acid consumption to promote cardiovascular health. Purpose: To summarize evidence about associations between fatty acids and coronary disease. Data Sources: MEDLINE, Science ...
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Cost effective interventions for the prevention of cardiovascular disease in low and middle income countries: a systematic review 

      Shroufi, Amir; Chowdhury, Rajiv; Anchala, Raghupathy; Stevens, Sarah; Blanco, Patricia; Han, Tha; Niessen, Louis et al. (2013-03-28)
      Abstract Background While there is good evidence to show that behavioural and lifestyle interventions can reduce cardiovascular disease risk factors in affluent settings, less evidence exists in lower income settings.This ...
    • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. 

      Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella; Mendelson, Michael M; Conneely, Karen N; Tanaka, Toshiko; Colicino, Elena et al. (BioMed Central, 2016-12-12)
      BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade ...
    • Effects of natural and plant-based therapies on menopausal symptoms: a systematic review and meta-analysis 

      Franco, Oscar H; Chowdhury, Rajiv; Troup, Jenna; Voortman, Trudy; Kuntusor, Setor; Kavousi, Maryam; Oliver-Williams, Clare Teresa et al. (2016-12)
    • Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. 

      Strawbridge, Rona J; Silveira, Angela; Hoed, Marcel den; Gustafsson, Stefan; Luan, Jian'an; Rybin, Denis; Dupuis, Josée et al. (2017-11)
    • Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population. 

      Li, Yanping; Pan, An; Wang, Dong D; Liu, Xiaoran; Dhana, Klodian; Franco, Oscar H; Kaptoge, Stephen Kipkemoi et al. (Wolters Kluwer Health, 2018-04-30)
      ABSTRACT Background: Americans have a shorter life expectancy compared to almost all other high-income countries. We aim to estimate the impact of lifestyle factors on premature mortality and life expectancy in the US ...
    • Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function 

      Wild, Philipp S; Felix, Janine F; Schillert, Arne; Teumer, Alexander; Chen, Ming-Huei; Leening, Maarten JG; Völker, Uwe et al. (American Society for Clinical Investigation, 2017-05-01)
      BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. 

      Liu, Chunyu; Kraja, Aldi T; Smith, Jennifer A; Brody, Jennifer A; Franceschini, Nora; Bis, Joshua C; Rice, Kenneth et al. (2016-10)
    • Objective Measures of Activity in the Elderly: Distribution and Associations With Demographic and Health Factors. 

      Koolhaas, Chantal M; van, Rooij Frank JA; Schoufour, Josje D; Cepeda, Magda; Tiemeier, Henning; Brage, Soren; Franco, Oscar H (Elsevier, 2017-10)
    • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

      Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P et al. (Springer Nature, 2018-01)
      Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which ...
    • The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review. 

      Wen, Ke-Xin; Miliç, Jelena; El-Khodor, Bassem; Dhana, Klodian; Nano, Jana; Pulido, Tammy; Kraja, Bledar et al. (2016-01)
    • The role of DNA methylation in dyslipidaemia: A systematic review. 

      Braun, Kim VE; Voortman, Trudy; Dhana, Klodian; Troup, Jenna; Bramer, Wichor M; Troup, John; Chowdhury, Rajiv et al. (2016-10-13)