Now showing items 1-14 of 14

    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A; Johnson, Laura; Franco, Oscar H et al. (American College of Physicians, 2014-03-18)
      Background: Guidelines advocate changes in fatty acid consumption to promote cardiovascular health. Purpose: To summarize evidence about associations between fatty acids and coronary disease. Data Sources: MEDLINE, Science ...
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Cost effective interventions for the prevention of cardiovascular disease in low and middle income countries: a systematic review 

      Shroufi, Amir; Chowdhury, Rajiv; Anchala, Raghupathy; Stevens, Sarah; Blanco, Patricia; Han, Tha; Niessen, Louis et al. (2013-03-28)
    • DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases. 

      Ligthart, Symen; Marzi, Carola; Aslibekyan, Stella; Mendelson, Michael M; Conneely, Karen N; Tanaka, Toshiko; Colicino, Elena et al. (BioMed Central, 2016-12-12)
      BACKGROUND: Chronic low-grade inflammation reflects a subclinical immune response implicated in the pathogenesis of complex diseases. Identifying genetic loci where DNA methylation is associated with chronic low-grade ...
    • Effects of natural and plant-based therapies on menopausal symptoms: a systematic review and meta-analysis 

      Franco, Oscar H; Chowdhury, Rajiv; Troup, Jenna; Voortman, Trudy; Kuntusor, Setor; Kavousi, Maryam; Oliver-Williams, Clare Teresa et al. (2016-12)
    • Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation. 

      Strawbridge, Rona J; Silveira, Angela; Hoed, Marcel den; Gustafsson, Stefan; Luan, Jian'an; Rybin, Denis; Dupuis, Josée et al. (2017-11)
    • Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function 

      Wild, Philipp S; Felix, Janine F; Schillert, Arne; Teumer, Alexander; Chen, Ming-Huei; Leening, Maarten JG; Völker, Uwe et al. (American Society for Clinical Investigation, 2017-05-01)
      BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. 

      Liu, Chunyu; Kraja, Aldi T; Smith, Jennifer A; Brody, Jennifer A; Franceschini, Nora; Bis, Joshua C; Rice, Kenneth et al. (2016-10)
    • Objective Measures of Activity in the Elderly: Distribution and Associations With Demographic and Health Factors. 

      Koolhaas, Chantal M; van, Rooij Frank JA; Schoufour, Josje D; Cepeda, Magda; Tiemeier, Henning; Brage, Soren; Franco, Oscar H (Elsevier, 2017-10)
    • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

      Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P et al. (Springer Nature, 2018-01)
      Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which ...
    • The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review. 

      Wen, Ke-Xin; Miliç, Jelena; El-Khodor, Bassem; Dhana, Klodian; Nano, Jana; Pulido, Tammy; Kraja, Bledar et al. (2016-01)
    • The role of DNA methylation in dyslipidaemia: A systematic review. 

      Braun, Kim VE; Voortman, Trudy; Dhana, Klodian; Troup, Jenna; Bramer, Wichor M; Troup, John; Chowdhury, Rajiv et al. (2016-10-13)