Now showing items 9-15 of 15

    • Large-scale genome-wide analysis identifies genetic variants associated with cardiac structure and function 

      Wild, Philipp S; Felix, Janine F; Schillert, Arne; Teumer, Alexander; Chen, Ming-Huei; Leening, Maarten JG; Völker, Uwe et al. (American Society for Clinical Investigation, 2017-05-01)
      BACKGROUND: Understanding the genetic architecture of cardiac structure and function may help to prevent and treat heart disease. This investigation sought to identify common genetic variations associated with inter-individual ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • Meta-analysis identifies common and rare variants influencing blood pressure and overlapping with metabolic trait loci. 

      Liu, Chunyu; Kraja, Aldi T; Smith, Jennifer A; Brody, Jennifer A; Franceschini, Nora; Bis, Joshua C; Rice, Kenneth et al. (2016-10)
    • Objective Measures of Activity in the Elderly: Distribution and Associations With Demographic and Health Factors. 

      Koolhaas, Chantal M; van, Rooij Frank JA; Schoufour, Josje D; Cepeda, Magda; Tiemeier, Henning; Brage, Soren; Franco, Oscar H (Elsevier, 2017-10)
    • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

      Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P et al. (Springer Nature, 2018-01)
      Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which ...
    • The Role of DNA Methylation and Histone Modifications in Neurodegenerative Diseases: A Systematic Review. 

      Wen, Ke-Xin; Miliç, Jelena; El-Khodor, Bassem; Dhana, Klodian; Nano, Jana; Pulido, Tammy; Kraja, Bledar et al. (2016-01)
    • The role of DNA methylation in dyslipidaemia: A systematic review. 

      Braun, Kim VE; Voortman, Trudy; Dhana, Klodian; Troup, Jenna; Bramer, Wichor M; Troup, John; Chowdhury, Rajiv et al. (2016-10-13)