Now showing items 4-23 of 31

    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (Massachusetts Medical Society, 2016-03-02)
      BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016) 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; Koenig, Inke R; Weeke, Peter E et al. (2016-05-12)
    • A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study. 

      Imamura, Fumiaki; Sharp, Stephen John; Koulman, Albert; Schulze, Matthias B; Kröger, Janine; Griffin, Julian Leether; Huerta, José M et al. (Public Library of Science (PLoS), 2017-10-11)
      Background: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. Methods ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek et al. (2016-06-29)
    • Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 

      Zamora-Ros, Raul; Forouhi, Nita Gandhi; Sharp, Stephen John; Gonzalez, Carlos A; Buijsse, Brian; Guevara, Marcela; van, der Schouw Yvonne T et al. (The American Society for Nutrition, 2013-12-24)
      Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability ...
    • Erratum. Dietary protein intake and incidence of type 2 diabetes in europe: the EPIC-InterAct case-cohort study. Diabetes Care 2014;37:1854-1862. 

      van Nielen, Monique; Feskens, Edith JM; Mensink, Marco; Sluijs, Ivonne; Molina, Esther; Amiano, Pilar; Ardanaz, Eva et al. (2015-10)
    • Estimation of free-living energy expenditure by heart rate and movement sensing: A doubly-labelled water study 

      Brage, Soren; Westgate, Kathryn Louise; Franks, Paul W; Stegle, Oliver; Wright, Antony; Ekelund, Ulf Mikael; Wareham, Nicholas John (PLOS, 2015-09-08)
      Background: Accurate assessment of energy expenditure (EE) is important for the study of energy balance and metabolic disorders. Combined heart rate (HR) and acceleration (ACC) sensing may increase precision of physical ...
    • An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. 

      Scott, Robert A; Scott, Laura J; Mägi, Reedik; Marullo, Letizia; Gaulton, Kyle J; Kaakinen, Marika; Pervjakova, Natalia et al. (American Diabetes Association, 2017-11-01)
      To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ...
    • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. 

      Corbin, Laura J; Tan, Vanessa Y; Hughes, David A; Wade, Kaitlin H; Paul, Dirk Stefan; Tansey, Katherine E; Butcher, Frances et al. (Springer Nature, 2018-02-19)
      Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. 

      Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha et al. (2015-12)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between height ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, Tuomas O; Carli, Jayne F Martin; Skowronski, Alicja A; Sun, Qi; Kriebel, Jennifer; Feitosa, Mary F; Hedman, Åsa K et al. (Nature Publishing Group, 2016-02-01)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 

      Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L; Feitosa, Mary F; Barata, Llilda; Winkler, Thomas W et al. (2017-04-27)
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk 

      Brænne, Ingrid; Zeng, Lingyao; Willenborg, Christina; Tragante, Vinicius; Kessler, Thorsten; CARDIoGRAM Consortium,; CARDIoGRAMplusC4D Consortium, et al. (PloS, 2017-08-22)
      Glatiramer acetate is used therapeutically in multiple sclerosis but also known for adverse effects including elevated coronary artery disease (CAD) risk. The mechanisms underlying the cardiovascular side effects of the ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. 

      Scott, Robert; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke et al. (2012-05)