Now showing items 1-3 of 3

    • Integration of metabolomics, lipidomics and clinical data using a machine learning method 

      Acharjee, Animesh; Ament, Zsuzsanna; West, James A; Stanley, Elizabeth; Griffin, Julian L (2016-11-22)
      Abstract Background The recent pandemic of obesity and the metabolic syndrome (MetS) has led to the realisation that new drug targets are needed to either reduce obesity ...
    • Metabolic basis to Sherpa altitude adaptation. 

      Horscroft, James A; Kotwica, Aleksandra O; Laner, Verena; West, James A; Hennis, Philip J; Levett, Denny ZH; Howard, David J et al. (National Academy of Sciences, 2017-06)
      The Himalayan Sherpas, a human population of Tibetan descent, are highly adapted to life in the hypobaric hypoxia of high altitude. Mechanisms involving enhanced tissue oxygen delivery in comparison with Lowlander populations, ...
    • Nitrate enhances skeletal muscle fatty acid oxidation via a nitric oxide-cGMP-PPAR-mediated mechanism 

      Ashmore, Tom; Roberts, Lee D; Morash, Andrea J; Kotwica, Aleksandra O; Finnerty, John; West, James A; Murfitt, Steven A et al. (2015-12-22)
      Abstract Background Insulin sensitivity in skeletal muscle is associated with metabolic flexibility, including a high capacity to increase fatty acid (FA) oxidation in response ...