Now showing items 1-3 of 3

    • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing 

      Easton, Douglas F; Lesueur, Fabienne; Decker, Brennan; Michailidou, Kyriaki; Li, Jun; Allen, Jamie; Luccarini, Craig et al. (BMJ Group, 2016-02-26)
      Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and ...
    • Prevalence and Penetrance of Major Genes and Polygenes for Colorectal Cancer. 

      Win, Aung Ko; Jenkins, Mark A; Dowty, James G; Antoniou, Antonis C; Lee, Andrew; Giles, Graham G; Buchanan, Daniel D et al. (American Association for Cancer Research, 2016-10-31)
      BACKGROUND: While high-risk mutations in identified major susceptibility genes (DNA mismatch repair genes and MUTYH) account for some familial aggregation of colorectal cancer, their population prevalence and the causes ...
    • Using mammographic density to predict breast cancer risk: dense area or percent dense area 

      Stone, Jennifer; Ding, Jane; Warren, Ruth M. L.; Duffy, Stephen; Hopper, John L (2010-11-18)
      Abstract Introduction Mammographic density (MD) is one of the strongest risk factors for breast cancer. It is not clear whether this association is best expressed in terms of absolute dense area or percentage dense area ...