Now showing items 4-5 of 5

    • Origins of chromosomal rearrangement hotspots in the human genome: evidence from the AZFadeletion hotspots 

      Hurles, Matthew E; Willey, David; Matthews, Lucy; Hussain, Syed Sufyan (2004-07-14)
      Abstract Background The origins of the recombination hotspots that are a common feature of both allelic and non-allelic homologous recombination in the human genome are poorly understood. We have investigated, by comparative ...
    • TRAIP promotes DNA damage response during genome replication and is mutated in primordial dwarfism 

      Harley, Margaret E; Murina, Olga; Leitch, Andrea; Higgs, Martin R; Bicknell, Louise S; Yigit, Gökhan; Blackford, Andrew Nicholas et al. (NPG, 2015-11-23)
      DNA lesions encountered by replicative polymerases threaten genome stability and cell cycle progression. Here we report the identification of mutations in TRAIP, encoding an E3 RING ubiquitin ligase, in patients with ...