Now showing items 1-20 of 45

    • Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study 

      Ye, Zheng; Sharp, Stephen John; Burgess, Stephen; Scott, Robert; Imamura, Fumiaki; InterAct, Consortium; Langenberg, Claudia et al. (2014-09-30)
    • Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis 

      Lotta, Luca Andrea; Sharp, Stephen John; Burgess, Stephen; Perry, John Richard; Stewart, Isobel Dorothea; Willems, Sara Marie; Luan, Jian'an et al. (American Medical Association, 2016-10-04)
      IMPORTANCE: Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near $\textit{NPC1L1}$ or $\textit{HMGCR}$, encoding the respective molecular targets of ezetimibe and statins, have previously been used as ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (2016-02-09)
    • Association of plasma phospholipid n-3 and n-6 polyunsaturated fatty acids with type 2 diabetes: The EPIC-InterAct case-cohort study 

      Forouhi, Nita G.; Imamura, Fumiaki; Sharp, Stephen J.; Koulman, Albert; Schulze, Matthias B.; Zheng, Jusheng; Ye, Zheng et al. (Public Library of Science, 2016-07-19)
      ${\bf Background:}$ Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. ${\bf ...
    • Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study. 

      Forouhi, Nita Gandhi; Imamura, Fumiaki; Sharp, Stephen John; Koulman, Albert; Schulze, Matthias B; Zheng, Jusheng; Ye, Zheng et al. (2016-07-19)
      BACKGROUND: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. METHODS AND FINDINGS: ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (2014-06-19)
    • Definitions of metabolic health and risk of future type 2 diabetes in body mass index categories: a systematic review and network meta-analysis 

      Lotta, Luca Andrea; Abbasi, Ali; Sharp, Stephen John; Sahlqvist, Anna-Stina; Waterworth, Dawn; Brosnan, Julia M; Scott, Robert et al. (2015-08-18)
    • Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 

      Zamora-Ros, Raul; Forouhi, Nita Gandhi; Sharp, Stephen John; Gonzalez, Carlos A; Buijsse, Brian; Guevara, Marcela; van, der Schouw Yvonne T et al. (2013-12-24)
    • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. 

      Iotchkova, V; Huang, J; Morris, JA; Jain, D; Barbieri, C; Walter, K; Min, JL et al. (Nature Publishing Group, 2016-11)
      Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 ...
    • Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis 

      Nead, Kevin T; Sharp, Stephen John; Thompson, Deborah Jane; Painter, Jodie N; Savage, David Bousfield; Semple, Robert Kenneth; Barker, Adam et al. (2015)
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

      Yaghootkar, Hanieh; Lotta, Luca Andrea; Tyrrell, Jessica; Smit, Roelof AJ; Jones, Sam E; Donnelly, Louise; Beaumont, Robin et al. (2016-04-26)
    • Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS) 

      Jensen, Rikke Beck; Thankamony, Ajay; Day, Felix Ranulf; Scott, Robert; Langenberg, Claudia; Kirk, Jeremy; Donaldson, Malcolm et al. (2014-12-12)
    • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis 

      Lotta, Luca Andrea; Scott, Robert; Sharp, Stephen John; Burgess, Stephen; Luan, Jian'an; Tillin, T; Schmidt, AF et al. (PLoS, 2016-11-29)
      $\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
    • Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. 

      Wright, Daniel; Day, Felix Ranulf; Kerrison, Nicola D; Zink, Florian; Cardona, Alexia; Sulem, Patrick; Thompson, Deborah Jane et al. (Nature Publishing Group, 2017-05)
      The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association study meta-analysis for quantitative ultrasound parameters of bone identifies five novel loci for broadband ultrasound attenuation 

      Mullin, BH; Zhao, Jing Hua; Brown, SJ; Perry, JRB; Luan, Jian'an; Zheng, HF; Langenberg, Claudia et al. (Oxford University Press, 2017-05-04)
      Osteoporosis is a common and debilitating bone disease that is characterised by low bone mineral density, typically assessed using dual-energy X-ray absorptiometry. Quantitative ultrasound (QUS), commonly utilising the two ...
    • Genome-wide associations for birth weight and correlations with adult disease 

      Horikoshi, M; Beaumont, RN; Day, Felix Ranulf; Warrington, NM; Kooijman, MN; Fernandez-Tajes, J; Feenstra, B et al. (Nature Publishing Group, 2016-10-13)
      Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and ...
    • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

      Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L et al. (Nature Publishing Group, 2017-04-26)
      Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, Tuomas O; Carli, Jayne F Martin; Skowronski, Alicja A; Sun, Qi; Kriebel, Jennifer; Feitosa, Mary F; Hedman, Åsa K et al. (2016-02-01)