Now showing items 1-20 of 57

    • Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study 

      Ye, Zheng; Sharp, Stephen John; Burgess, Stephen; Scott, Robert; Imamura, Fumiaki; InterAct, Consortium; Langenberg, Claudia et al. (Elsevier, 2014-09-30)
      Background: Low circulating concentrations of 25-hydroxyvitamin D (25[OH]D), a marker of vitamin D status, are associated with an increased risk of type 2 diabetes, but whether this association is causal remains unclear. ...
    • Association Between Low-Density Lipoprotein Cholesterol-Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis 

      Lotta, Luca Andrea; Sharp, Stephen John; Burgess, Stephen; Perry, John Richard; Stewart, Isobel Dorothea; Willems, Sara Marie; Luan, Jian'an et al. (American Medical Association, 2016-10-04)
      IMPORTANCE: Low-density lipoprotein cholesterol (LDL-C)-lowering alleles in or near $\textit{NPC1L1}$ or $\textit{HMGCR}$, encoding the respective molecular targets of ezetimibe and statins, have previously been used as ...
    • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study 

      Zheng, Ju-Sheng; Sharp, Stephen J; Imamura, Fumiaki; Koulman, Albert; Schulze, Matthias B; Ye, Zheng; Griffin, Jules et al. (2017-11-17)
      Abstract Background Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (American Diabetes Association, 2016-02-09)
      Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, ...
    • Association of plasma phospholipid n-3 and n-6 polyunsaturated fatty acids with type 2 diabetes: The EPIC-InterAct case-cohort study 

      Forouhi, Nita G.; Imamura, Fumiaki; Sharp, Stephen J.; Koulman, Albert; Schulze, Matthias B.; Zheng, Jusheng; Ye, Zheng et al. (Public Library of Science, 2016-07-19)
      ${\bf Background:}$ Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. ${\bf ...
    • Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study. 

      Forouhi, Nita Gandhi; Imamura, Fumiaki; Sharp, Stephen John; Koulman, Albert; Schulze, Matthias B; Zheng, Jusheng; Ye, Zheng et al. (2016-07-19)
      BACKGROUND: Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. METHODS AND FINDINGS: ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek et al. (2016-06-29)
    • Definitions of metabolic health and risk of future type 2 diabetes in body mass index categories: a systematic review and network meta-analysis 

      Lotta, Luca Andrea; Abbasi, Ali; Sharp, Stephen John; Sahlqvist, Anna-Stina; Waterworth, Dawn; Brosnan, Julia M; Scott, Robert et al. (2015-08-18)
    • Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 

      Zamora-Ros, Raul; Forouhi, Nita Gandhi; Sharp, Stephen John; Gonzalez, Carlos A; Buijsse, Brian; Guevara, Marcela; van, der Schouw Yvonne T et al. (2013-12-24)
    • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. 

      Iotchkova, V; Huang, J; Morris, JA; Jain, D; Barbieri, C; Walter, K; Min, JL et al. (Nature Publishing Group, 2016-11)
      Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 ...
    • Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis 

      Nead, Kevin T; Sharp, Stephen John; Thompson, Deborah Jane; Painter, Jodie N; Savage, David Bousfield; Semple, Robert Kenneth; Barker, Adam et al. (Oxford University Press, 2015)
      Background: Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian ...
    • An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. 

      Scott, Robert A; Scott, Laura J; Mägi, Reedik; Marullo, Letizia; Gaulton, Kyle J; Kaakinen, Marika; Pervjakova, Natalia et al. (American Diabetes Association, 2017-11-01)
      To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

      Yaghootkar, Hanieh; Lotta, Luca Andrea; Tyrrell, Jessica; Smit, Roelof AJ; Jones, Sam E; Donnelly, Louise; Beaumont, Robin et al. (American Diabetes Association, 2016-04-26)
      Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These “favorable adiposity” alleles are collectively associated with lower ...
    • Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. 

      Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha et al. (2015-12)
    • Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS) 

      Jensen, Rikke Beck; Thankamony, Ajay; Day, Felix Ranulf; Scott, Robert; Langenberg, Claudia; Kirk, Jeremy; Donaldson, Malcolm et al. (2014-12-12)
    • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis 

      Lotta, Luca Andrea; Scott, Robert; Sharp, Stephen John; Burgess, Stephen; Luan, Jian'an; Tillin, T; Schmidt, AF et al. (PLoS, 2016-11-29)
      $\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
    • Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. 

      Wright, Daniel; Day, Felix Ranulf; Kerrison, Nicola D; Zink, Florian; Cardona, Alexia; Sulem, Patrick; Thompson, Deborah Jane et al. (Nature Publishing Group, 2017-05)
      The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)