Now showing items 8-27 of 72

    • A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study. 

      Imamura, Fumiaki; Sharp, Stephen John; Koulman, Albert; Schulze, Matthias B; Kröger, Janine; Griffin, Julian Leether; Huerta, José M et al. (Public Library of Science (PLoS), 2017-10-11)
      Background: Combinations of multiple fatty acids may influence cardiometabolic risk more than single fatty acids. The association of a combination of fatty acids with incident type 2 diabetes (T2D) has not been evaluated. Methods ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek et al. (2016-06-29)
    • The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England: A microsimulation study. 

      Mytton, Oliver Tristan; Jackson, Christopher Hamilton; Steinacher, Arno; Goodman, Anna; Langenberg, Claudia; Griffin, Simon James; Wareham, Nicholas John et al. (Public Library of Science (PLoS), 2018-03-06)
      Abstract Background: The NHS Health Check Programme was introduced in 2009 in England to systematically assess all adults in mid-life for cardiovascular disease risk factors, but its current benefit and impact on health ...
    • Definitions of metabolic health and risk of future type 2 diabetes in body mass index categories: a systematic review and network meta-analysis 

      Lotta, Luca Andrea; Abbasi, Ali; Sharp, Stephen John; Sahlqvist, Anna-Stina; Waterworth, Dawn; Brosnan, Julia M; Scott, Robert et al. (2015-08-18)
      Objective: Various definitions of metabolic health have been proposed to explain differences in the risk of type 2 diabetes within body mass index (BMI) categories. The goal of this study was to assess their predictive ...
    • Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 

      Zamora-Ros, Raul; Forouhi, Nita Gandhi; Sharp, Stephen John; Gonzalez, Carlos A; Buijsse, Brian; Guevara, Marcela; van, der Schouw Yvonne T et al. (The American Society for Nutrition, 2013-12-24)
      Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability ...
    • Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. 

      Iotchkova, V; Huang, J; Morris, JA; Jain, D; Barbieri, C; Walter, K; Min, JL et al. (Nature Publishing Group, 2016-11)
      Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 ...
    • Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes. 

      Mardinoglu, Adil; Gogg, Silvia; Lotta, Luca Andrea; Stančáková, Alena; Nerstedt, Annika; Boren, Jan; Blüher, Matthias et al. (2018-01)
    • Erratum. Dietary protein intake and incidence of type 2 diabetes in europe: the EPIC-InterAct case-cohort study. Diabetes Care 2014;37:1854-1862. 

      van Nielen, Monique; Feskens, Edith JM; Mensink, Marco; Sluijs, Ivonne; Molina, Esther; Amiano, Pilar; Ardanaz, Eva et al. (2015-10)
    • Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis 

      Nead, Kevin T; Sharp, Stephen John; Thompson, Deborah Jane; Painter, Jodie N; Savage, David Bousfield; Semple, Robert Kenneth; Barker, Adam et al. (Oxford University Press, 2015)
      Background: Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian ...
    • Exome-wide association study of plasma lipids in >300,000 individuals. 

      Liu, Dajiang J; Peloso, Gina M; Yu, Haojie; Butterworth, Adam Stuart; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish et al. (Springer Nature, 2017-12)
      We report four novel loci associated with blood pressure regulation, and one independent variant at an established blood pressure locus. This analysis highlights several candidate genes with variation that alters protein ...
    • An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. 

      Scott, Robert A; Scott, Laura J; Mägi, Reedik; Marullo, Letizia; Gaulton, Kyle J; Kaakinen, Marika; Pervjakova, Natalia et al. (American Diabetes Association, 2017-11-01)
      To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

      Yaghootkar, Hanieh; Lotta, Luca Andrea; Tyrrell, Jessica; Smit, Roelof AJ; Jones, Sam E; Donnelly, Louise; Beaumont, Robin et al. (American Diabetes Association, 2016-04-26)
      Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These “favorable adiposity” alleles are collectively associated with lower ...
    • Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci. 

      Gaulton, Kyle J; Ferreira, Teresa; Lee, Yeji; Raimondo, Anne; Mägi, Reedik; Reschen, Michael E; Mahajan, Anubha et al. (2015-12)
    • Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS) 

      Jensen, Rikke Beck; Thankamony, Ajay; Day, Felix Ranulf; Scott, Robert; Langenberg, Claudia; Kirk, Jeremy; Donaldson, Malcolm et al. (Endocrine Society, 2014-12-12)
      Purpose: The wide heterogeneity in the early growth and metabolism of children born small for gestational age (SGA), both before and during growth hormone (GH) therapy, may reflect common genetic variations related to ...
    • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis 

      Lotta, Luca Andrea; Scott, Robert; Sharp, Stephen John; Burgess, Stephen; Luan, Jian'an; Tillin, T; Schmidt, AF et al. (PLoS, 2016-11-29)
      $\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
    • Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. 

      Wright, Daniel; Day, Felix Ranulf; Kerrison, Nicola D; Zink, Florian; Cardona, Alexia; Sulem, Patrick; Thompson, Deborah Jane et al. (Nature Publishing Group, 2017-05)
      The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations 

      Prins, Bram Peter; Kuchenbaecker, Karoline B; Bao, Yanchun; Smart, Melissa; Zabaneh, Delilah; Fatemifar, Ghazaleh; Luan, Jian'an et al. (Springer Nature, 2017-09-08)
      Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits which can reflect health status. We performed genome-wide association ...