Now showing items 12-31 of 72

• #### Definitions of metabolic health and risk of future type 2 diabetes in body mass index categories: a systematic review and network meta-analysis ﻿

(2015-08-18)
Objective: Various definitions of metabolic health have been proposed to explain differences in the risk of type 2 diabetes within body mass index (BMI) categories. The goal of this study was to assess their predictive ...
• #### Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations ﻿

(The American Society for Nutrition, 2013-12-24)
Dietary flavanols and flavonols, flavonoid subclasses, have been recently associated with a lower risk of type 2 diabetes (T2D) in Europe. Even within the same subclass, flavonoids may differ considerably in bioavailability ...
• #### Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps. ﻿

(Nature Publishing Group, 2016-11)
Large-scale whole-genome sequence data sets offer novel opportunities to identify genetic variation underlying human traits. Here we apply genotype imputation based on whole-genome sequence data from the UK10K and 1000 ...

(2018-01)

(2015-10)
• #### Evidence of a causal association between insulinemia and endometrial cancer: A Mendelian randomization analysis ﻿

(Oxford University Press, 2015)
Background: Insulinemia and type 2 diabetes (T2D) have been associated with endometrial cancer risk in numerous observational studies. However, the causality of these associations is uncertain. Here we use a Mendelian ...
• #### Exome-wide association study of plasma lipids in >300,000 individuals. ﻿

(Springer Nature, 2017-12)
We report four novel loci associated with blood pressure regulation, and one independent variant at an established blood pressure locus. This analysis highlights several candidate genes with variation that alters protein ...
• #### An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans. ﻿

(American Diabetes Association, 2017-11-01)
To characterize type 2 diabetes (T2D)-associated variation across the allele frequency spectrum, we conducted a meta-analysis of genome-wide association data from 26,676 T2D case and 132,532 control subjects of European ...
• #### The genetic architecture of type 2 diabetes. ﻿

(2016-08)
The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
• #### Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. ﻿

(American Diabetes Association, 2016-04-26)
Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These “favorable adiposity” alleles are collectively associated with lower ...

(2015-12)
• #### Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS) ﻿

(Endocrine Society, 2014-12-12)
Purpose: The wide heterogeneity in the early growth and metabolism of children born small for gestational age (SGA), both before and during growth hormone (GH) therapy, may reflect common genetic variations related to ...
• #### Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis ﻿

(PLoS, 2016-11-29)
$\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
• #### Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. ﻿

(Nature Publishing Group, 2017-05)
The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...

(2016-10)
• #### Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations ﻿

(Springer Nature, 2017-09-08)
Serum biomarker levels are associated with the risk of complex diseases. Here, we aimed to gain insights into the genetic architecture of biomarker traits which can reflect health status. We performed genome-wide association ...

(2011-10)
• #### A genome-wide association search for type 2 diabetes genes in African Americans. ﻿

(2012-01-04)
• #### Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. ﻿

(2018-01-17)
Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, ...
• #### Genome-wide association study meta-analysis for quantitative ultrasound parameters of bone identifies five novel loci for broadband ultrasound attenuation ﻿

(Oxford University Press, 2017-05-04)
Osteoporosis is a common and debilitating bone disease that is characterised by low bone mineral density, typically assessed using dual-energy X-ray absorptiometry. Quantitative ultrasound (QUS), commonly utilising the two ...