Now showing items 10-29 of 41

    • Genetic evidence for a link between favorable adiposity and lower risk of type 2 diabetes, hypertension and heart disease. 

      Yaghootkar, Hanieh; Lotta, Luca A.; Tyrrell, Jessica; Smit, Roelof A. J.; Jones, Sam E.; Donnelly, Louise; Beaumont, Robin et al. (American Diabetes Association, 2016-04-26)
      Recent genetic studies have identified some alleles associated with higher BMI but lower risk of type 2 diabetes, hypertension and heart disease. These “favorable adiposity” alleles are collectively associated with lower ...
    • Genetic markers of insulin sensitivity and insulin secretion are associated with spontaneous postnatal growth and response to growth hormone treatment in short SGA children: the North European SGA Study (NESGAS) 

      Jensen, Rikke Beck; Thankamony, Ajay; Day, Felix; Scott, Robert A.; Langenberg, Claudia; Kirk, Jeremy; Donaldson, Malcolm et al. (Endocrine Society, 2014-12-12)
      Purpose: The wide heterogeneity in the early growth and metabolism of children born small for gestational age (SGA), both before and during growth hormone (GH) therapy, may reflect common genetic variations related to ...
    • Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis 

      Lotta, Luca Andrea; Scott, Robert; Sharp, Stephen John; Burgess, Stephen; Luan, Jian'an; Tillin, T; Schmidt, AF et al. (PLoS, 2016-11-29)
      $\textbf{BACKGROUND}$: Higher circulating levels of the branched-chain amino acids (BCAAs; i.e., isoleucine, leucine, and valine) are strongly associated with higher type 2 diabetes risk, but it is not known whether this ...
    • Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility. 

      Wright, Daniel; Day, Felix Ranulf; Kerrison, Nicola D; Zink, Florian; Cardona, Alexia; Sulem, Patrick; Thompson, Deborah Jane et al. (Nature Publishing Group, 2017-05)
      The Y-chromosome is frequently lost in hematopoietic cells, representing the most common somatic mutation in men. However, the mechanisms regulating mosaic loss of chromosomeY (mLOY), and its clinical relevance, are unknown. ...
    • Genome-wide association study meta-analysis for quantitative ultrasound parameters of bone identifies five novel loci for broadband ultrasound attenuation 

      Mullin, BH; Zhao, Jing Hua; Brown, SJ; Perry, JRB; Luan, J; Zheng, HF; Langenberg, Claudia et al. (Oxford University Press, 2017-05-04)
      Osteoporosis is a common and debilitating bone disease that is characterised by low bone mineral density, typically assessed using dual-energy X-ray absorptiometry. Quantitative ultrasound (QUS), commonly utilising the two ...
    • Genome-wide associations for birth weight and correlations with adult disease 

      Horikoshi, M; Beaumont, RN; Day, Felix Ranulf; Warrington, NM; Kooijman, MN; Fernandez-Tajes, J; Feenstra, B et al. (Nature Publishing Group, 2016-10-13)
      Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and ...
    • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

      Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L et al. (Nature Publishing Group, 2017-04-26)
      Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
    • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels 

      Kilpeläinen, Tuomas O.; Carli, Jayne F. Martin; Skowronski, Alicja A.; Sun, Qi; Kriebel, Jennifer; Feitosa, Mary F.; Hedman, Åsa K. et al. (Nature Publishing Group, 2016-02-01)
      Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 

      Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L; Feitosa, Mary F; Barata, Llilda; Winkler, Thomas W et al. (2017-04-27)
    • Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk 

      Day, Felix Ranulf; Thompson, Deborah Jane; Helgason, H; Chasman, DI; Finucane, H; Sulem, P; Ruth, KS et al. (Nature Publishing Group, 2017-04-24)
      The timing of puberty is a highly polygenic childhood trait that is epidemiologically associated with various adult diseases. Using 1000 Genomes Project–imputed genotype data in up to ~370,000 women, we identify 389 ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y.; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. 

      Lotta, Luca Andrea; Gulati, Pawan; Day, Felix Ranulf; Payne, Felicity; Ongen, Halit; van de Bunt, Martijn; Gaulton, Kyle J et al. (Nature Publishing Group, 2017-01)
      Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with ...
    • Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from EPIC-InterAct 

      Li, Xueyi; Imamura, F; Ye, Z; Schulze, MB; Zheng, J; Ardamaz, E; Arriola, L et al. (American Society for Clinical Nutrition, Inc., 2017-06-07)
      Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to ...
    • Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. 

      Nettleton, JA; McKeown, NM; Kanoni, S; Lemaitre, RN; Hivert, M-F; Ngwa, J; van Rooij, FJA et al. (American Diabetes Association, 2010-12)
      OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single ...
    • KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. 

      Schumann, G; Liu, C; O'Reilly, P; Gao, H; Song, P; Xu, B; Ruggeri, B et al. (National Academy of Sciences, 2016-12-13)
      Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a ...
    • Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness 

      Willems, SM; Wright, Daniel; Day, Felix Ranulf; Trajanoska, K; Joshi, PK; Morris, JA; Matteini, AM et al. (Nature Publishing Group, 2017-07-12)
      Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y.; Willems, Sara M.; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A.; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

      Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N et al. (American Diabetes Association, 2017-03-23)
      To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
    • Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. 

      InterAct Consortium,; Romaguera, D; Guevara, M; Norat, T; Langenberg, Claudia; Forouhi, Nita Gandhi; Sharp, S et al. (American Diabetes Association, 2011-09)
      OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort ...
    • Mendelian Randomisation study of the influence of eGFR on coronary heart disease. 

      Charoen, Pimphen; Nitsch, Dorothea; Engmann, Jorgen; Shah, Tina; White, Jonathan; Zabaneh, Delilah; Jefferis, Barbara et al. (2016-06-24)
      Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this ...