Now showing items 22-41 of 43

    • Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis 

      Wheeler, E; Leong, A; Liu, C-T; Hivert, M-F; Strawbridge, RJ; Podmore, Clara; Li, M et al. (Public Library of Science (PLoS), 2017-09)
      BACKGROUND: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated ...
    • Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. 

      Lotta, Luca Andrea; Gulati, Pawan; Day, Felix Ranulf; Payne, Felicity; Ongen, Halit; van, de Bunt Martijn; Gaulton, Kyle J et al. (Nature Publishing Group, Nature Publishing Group, 2017-01)
      Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with ...
    • Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from EPIC-InterAct 

      Li, Xueyi; Imamura, F; Ye, Z; Schulze, MB; Zheng, J; Ardamaz, E; Arriola, L et al. (American Society for Clinical Nutrition, Inc., American Society for Clinical Nutrition, Inc., 2017-06-07)
      Background: Gene-diet interactions have been reported to contribute to the development of type 2 diabetes (T2D). However, to our knowledge, few examples have been consistently replicated to date. Objective: We aimed to ...
    • Interactions of dietary whole-grain intake with fasting glucose- and insulin-related genetic loci in individuals of European descent: a meta-analysis of 14 cohort studies. 

      Nettleton, JA; McKeown, NM; Kanoni, S; Lemaitre, RN; Hivert, M-F; Ngwa, J; van, Rooij FJA et al. (American Diabetes Association, American Diabetes Association, 2010-12)
      OBJECTIVE: Whole-grain foods are touted for multiple health benefits, including enhancing insulin sensitivity and reducing type 2 diabetes risk. Recent genome-wide association studies (GWAS) have identified several single ...
    • KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference. 

      Schumann, G; Liu, C; O'Reilly, P; Gao, H; Song, P; Xu, B; Ruggeri, B et al. (National Academy of Sciences, National Academy of Sciences, 2016-12-13)
      Excessive alcohol consumption is a major public health problem worldwide. Although drinking habits are known to be inherited, few genes have been identified that are robustly linked to alcohol drinking. We conducted a ...
    • Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness 

      Willems, SM; Wright, Daniel; Day, Felix Ranulf; Trajanoska, K; Joshi, PK; Morris, JA; Matteini, AM et al. (Nature Publishing Group, Nature Publishing Group, 2017-07-12)
      Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
    • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

      Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N et al. (American Diabetes Association, American Diabetes Association, 2017-03-23)
      To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
    • Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. 

      InterAct, Consortium; Romaguera, D; Guevara, M; Norat, T; Langenberg, Claudia; Forouhi, Nita Gandhi; Sharp, S et al. (American Diabetes Association, American Diabetes Association, 2011-09)
      OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort ...
    • Mendelian Randomisation study of the influence of eGFR on coronary heart disease. 

      Charoen, Pimphen; Nitsch, Dorothea; Engmann, Jorgen; Shah, Tina; White, Jonathan; Zabaneh, Delilah; Jefferis, Barbara et al. (2016-06-24)
      Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this ...
    • MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai 

      Liu, Chen; Wu, Ying; Li, Huaixing; Qi, Qibin; Langenberg, Claudia; Loos, Ruth; Lin, Xu (2010-04-14)
    • Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults. 

      Varga, Tibor V; Kurbasic, Azra; Aine, Mattias; Eriksson, Pontus; Ali, Ashfaq; Hindy, George; Gustafsson, Stefan et al. (2017-08)
      BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term ...
    • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study 

      Schmidt, AF; Swerdlow, DI; Holmes, MV; Patel, RS; Fairhurst-Hunter, Z; Lyall, DM; Hartwig, FP et al. (Elsevier BV, Elsevier BV, 2017-02)
      BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest ...
    • Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions 

      Shungin, D; Deng, WQ; Varga, TV; Luan, J; Mihailov, E; Metspalu, A; GIANT Consortium, et al. (Public Library of Science (PLoS), 2017-06-14)
      Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and ...
    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di, Angelantonio Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Rare coding variants and X - linked loci associated with age at menarche 

      Lunetta, Kathryn L; Day, Felix Ranulf; Sulem, Patrick; Ruth, Katherine S; Tung, Joyce Y; Hinds, David A; Esko, Tõnu et al. (NPG, 2015-08-04)
    • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity 

      Hendricks, AE; Bochukova, EG; Marenne, G; Keogh, Julia Mary; Atanassova, N; Bounds, R; Wheeler, E et al.
      Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
    • Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans 

      McLachlan, Stela; Giambartolomei, Claudia; White, Jon; Charoen, Pimphen; Wong, Andrew; Finan, Chris; Engmann, Jorgen et al. (Public Library of Science, 2016-06-09)
    • A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature 

      Abbasi, Ali; Sahlqvist, A-S; Lotta, Luca Andrea; Brosnan, JM; Vollenweider, P; Giabbanelli, Philippe Joseph; Nunez, DJ et al. (PLOS, PLOS, 2016-10-27)
      $\textbf{BACKGROUND}$ Blood-based or urinary biomarkers may play a role in quantifying the future risk of type 2 diabetes (T2D) and in understanding possible aetiological pathways to disease. However, no systematic review ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels et al. (Nature Publishing Group, 2016-09-12)