Now showing items 41-60 of 67

    • Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness 

      Willems, SM; Wright, Daniel; Day, Felix Ranulf; Trajanoska, K; Joshi, PK; Morris, JA; Matteini, AM et al. (Nature Publishing Group, 2017-07-12)
      Hand grip strength is a widely used proxy of muscular fitness, a marker of frailty, and predictor of a range of morbidities and all-cause mortality. To investigate the genetic determinants of variation in grip strength, ...
    • Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. 

      Medina-Gomez, Carolina; Kemp, John P; Trajanoska, Katerina; Luan, Jian'an; Chesi, Alessandra; Ahluwalia, Tarunveer S; Mook-Kanamori, Dennis O et al. (2018-01)
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y; Willems, Sara Marie; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...
    • A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk 

      Manning, A; Highland, HM; Gasser, J; Sim, X; Tukiainen, T; Fontanillas, P; Grarup, N et al. (American Diabetes Association, 2017-03-23)
      To identify novel coding association signals and facilitate characterization of mechanisms influencing glycemic traits and type 2 diabetes risk, we analyzed 109,215 variants derived from exome array genotyping together ...
    • Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. 

      InterAct Consortium,; Romaguera, D; Guevara, M; Norat, T; Langenberg, Claudia; Forouhi, Nita Gandhi; Sharp, S et al. (American Diabetes Association, 2011-09)
      OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort ...
    • Mendelian Randomisation study of the influence of eGFR on coronary heart disease. 

      Charoen, Pimphen; Nitsch, Dorothea; Engmann, Jorgen; Shah, Tina; White, Jonathan; Zabaneh, Delilah; Jefferis, Barbara et al. (2016-06-24)
      Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this ...
    • MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai 

      Liu, Chen; Wu, Ying; Li, Huaixing; Qi, Qibin; Langenberg, Claudia; Loos, Ruth; Lin, Xu (2010-04-14)
      Abstract Background Genome-wide association studies (GWAS) in White Europeans have shown that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated with fasting glucose and type 2 diabetes, which ...
    • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 

      Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew Stephen; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes Carola et al. (Springer Nature, 2018-04)
      Stroke has multiple etiologies but the underlying genes and pathways are largely unknown. We conducted a multi-ancestry genome-wide association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and ...
    • No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. 

      Scott, Robert; Chu, Audrey Y; Grarup, Niels; Manning, Alisa K; Hivert, Marie-France; Shungin, Dmitry; Tönjes, Anke et al. (2012-05)
    • Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults. 

      Varga, Tibor V; Kurbasic, Azra; Aine, Mattias; Eriksson, Pontus; Ali, Ashfaq; Hindy, George; Gustafsson, Stefan et al. (2017-08)
      BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term ...
    • Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis. 

      Benyamin, Beben; Esko, Tonu; Ried, Janina S; Radhakrishnan, Aparna; Vermeulen, Sita H; Traglia, Michela; Gögele, Martin et al. (2014-10-29)
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John Richard; Yuan, Xin; Scott, Robert; Henneman, Peter et al. (2012-01)
    • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study 

      Schmidt, AF; Swerdlow, DI; Holmes, MV; Patel, RS; Fairhurst-Hunter, Z; Lyall, DM; Hartwig, FP et al. (Elsevier BV, 2017-02)
      BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest ...
    • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. 

      Ried, Janina S; Jeff M, Janina; Chu, Audrey Y; Bragg-Gresham, Jennifer L; van Dongen, Jenny; Huffman, Jennifer E; Ahluwalia, Tarunveer S et al. (2016-11-23)
    • Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. 

      Turcot, Valérie; Lu, Yingchang; Highland, Heather M; Schurmann, Claudia; Justice, Anne E; Fine, Rebecca S; Bradfield, Jonathan P et al. (Springer Nature, 2018-01)
      Genome-wide association studies (GWAS) have identified >250 loci for body mass index (BMI), implicating pathways related to neuronal biology. Most GWAS loci represent clusters of common, non-coding variants from which ...
    • Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions 

      Shungin, D; Deng, WQ; Varga, TV; Luan, Jian'an; Mihailov, E; Metspalu, A; GIANT Consortium, et al. (Public Library of Science (PLoS), 2017-06-14)
      Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and ...
    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di Angelantonio, Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Rare coding variants and X - linked loci associated with age at menarche 

      Lunetta, Kathryn L; Day, Felix Ranulf; Sulem, Patrick; Ruth, Katherine S; Tung, Joyce Y; Hinds, David A; Esko, Tõnu et al. (NPG, 2015-08-04)
      More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ~3% of the trait variance. Here we test two overlooked sources of variation in 192,974 ...
    • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. 

      Hendricks, Audrey E; Bochukova, Elena G; Marenne, Gaëlle; Keogh, Julia Mary; Atanassova, Neli; Bounds, Rebecca; Wheeler, Eleanor et al. (Nature Publishing Group, 2017-06-29)
      Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
    • Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes. 

      Bonàs-Guarch, Sílvia; Guindo-Martínez, Marta; Miguel-Escalada, Irene; Grarup, Niels; Sebastian, David; Rodriguez-Fos, Elias; Sánchez, Friman et al. (2018-01-22)