Now showing items 28-41 of 41

    • Mediterranean diet and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) study: the InterAct project. 

      InterAct Consortium,; Romaguera, D; Guevara, M; Norat, T; Langenberg, Claudia; Forouhi, Nita Gandhi; Sharp, S et al. (American Diabetes Association, 2011-09)
      OBJECTIVE: To study the association between adherence to the Mediterranean dietary pattern (MDP) and risk of developing type 2 diabetes, across European countries. RESEARCH DESIGN AND METHODS: We established a case-cohort ...
    • Mendelian Randomisation study of the influence of eGFR on coronary heart disease. 

      Charoen, Pimphen; Nitsch, Dorothea; Engmann, Jorgen; Shah, Tina; White, Jonathan; Zabaneh, Delilah; Jefferis, Barbara et al. (2016-06-24)
      Impaired kidney function, as measured by reduced estimated glomerular filtration rate (eGFR), has been associated with increased risk of coronary heart disease (CHD) in observational studies, but it is unclear whether this ...
    • MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1C and impaired beta-cell function in Chinese Hans from Shanghai 

      Liu, Chen; Wu, Ying; Li, Huaixing; Qi, Qibin; Langenberg, Claudia; Loos, Ruth J. F.; Lin, Xu (2010-04-14)
      Abstract Background Genome-wide association studies (GWAS) in White Europeans have shown that genetic variation rs10830963 in melatonin receptor 1B gene (MTNR1B) is associated with fasting glucose and type 2 diabetes, which ...
    • Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults. 

      Varga, Tibor V; Kurbasic, Azra; Aine, Mattias; Eriksson, Pontus; Ali, Ashfaq; Hindy, George; Gustafsson, Stefan et al. (2016-11-17)
      BACKGROUND: Cross-sectional genome-wide association studies have identified hundreds of loci associated with blood lipids and related cardiovascular traits, but few genetic association studies have focused on long-term ...
    • PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study 

      Schmidt, AF; Swerdlow, DI; Holmes, MV; Patel, RS; Fairhurst-Hunter, Z; Lyall, DM; Hartwig, FP et al. (Elsevier BV, 2017-02)
      BACKGROUND: Statin treatment and variants in the gene encoding HMG-CoA reductase are associated with reductions in both the concentration of LDL cholesterol and the risk of coronary heart disease, but also with modest ...
    • Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions 

      Shungin, D; Deng, WQ; Varga, TV; Luan, J; Mihailov, E; Metspalu, A; GIANT Consortium, et al. (Public Library of Science (PLoS), 2017-06-14)
      Phenotypic variance heterogeneity across genotypes at a single nucleotide polymorphism (SNP) may reflect underlying gene-environment (G×E) or gene-gene interactions. We modeled variance heterogeneity for blood lipids and ...
    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di Angelantonio, Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Rare coding variants and X - linked loci associated with age at menarche 

      Lunetta, Kathryn L.; Day, Felix; Sulem, Patrick; Ruth, Katherine S.; Tung, Joyce Y.; Hinds, David A.; Esko, Tõnu et al. (NPG, 2015-08-04)
      More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ~3% of the trait variance. Here we test two overlooked sources of variation in 192,974 ...
    • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity 

      Hendricks, AE; Bochukova, EG; Marenne, G; Keogh, Julia Mary; Atanassova, N; Bounds, R; Wheeler, E et al.
      Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
    • Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans 

      McLachlan, Stela; Giambartolomei, Claudia; White, Jon; Charoen, Pimphen; Wong, Andrew; Finan, Chris; Engmann, Jorgen et al. (Public Library of Science, 2016-06-09)
      Red blood cell (RBC) traits are routinely measured in clinical practice as important markers of health. Deviations from the physiological ranges are usually a sign of disease, although variation between healthy individuals ...
    • A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature 

      Abbasi, Ali; Sahlqvist, A-S; Lotta, Luca Andrea; Brosnan, JM; Vollenweider, P; Giabbanelli, Philippe Joseph; Nunez, DJ et al. (PLOS, 2016-10-27)
      $\textbf{BACKGROUND}$ Blood-based or urinary biomarkers may play a role in quantifying the future risk of type 2 diabetes (T2D) and in understanding possible aetiological pathways to disease. However, no systematic review ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P.; Manning, Alisa K.; Grarup, Niels et al. (Nature Publishing Group, 2016-09-12)
      High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we ...
    • Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes: Mendelian randomization study 

      Larsson, SC; Scott, RA; Traylor, M; Langenberg, Claudia; Hindy, G; Melander, O; Orho-Melander, M et al. (Wolters Kluwer, 2017-08-01)
      $\textbf{Objective:}$ To implement a mendelian randomization (MR) approach to determine whether type 2 diabetes mellitus (T2D), fasting glucose, fasting insulin, and body mass index (BMI) are causally associated with ...
    • Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits 

      Tachmazidou, I; Süveges, D; Min, JL; Ritchie, GRS; Steinberg, J; Walter, K; Iotchkova, V et al. (Elsevier (Cell Press), 2017-06-01)
      Deep sequence-based imputation can enhance the discovery power of genome-wide association studies by assessing previously unexplored variation across the common- and low-frequency spectra. We applied a hybrid whole-genome ...