Now showing items 14-16 of 16

    • Rare coding variants and X - linked loci associated with age at menarche 

      Lunetta, Kathryn L.; Day, Felix; Sulem, Patrick; Ruth, Katherine S.; Tung, Joyce Y.; Hinds, David A.; Esko, Tõnu et al. (NPG, 2015-08-04)
      More than 100 loci have been identified for age at menarche by genome-wide association studies; however, collectively these explain only ~3% of the trait variance. Here we test two overlooked sources of variation in 192,974 ...
    • Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans 

      McLachlan, Stela; Giambartolomei, Claudia; White, Jon; Charoen, Pimphen; Wong, Andrew; Finan, Chris; Engmann, Jorgen et al. (Public Library of Science, 2016-06-09)
      Red blood cell (RBC) traits are routinely measured in clinical practice as important markers of health. Deviations from the physiological ranges are usually a sign of disease, although variation between healthy individuals ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P.; Manning, Alisa K.; Grarup, Niels et al. (Nature Publishing Group, 2016-09-12)
      High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we ...