Now showing items 1-6 of 6

    • Differences in Common Genetic Predisposition to Ischaemic Stroke by Age and Sex 

      Traylor, Matthew Stephen; Rutten-Jacobs, Loes Carola; Holliday, Elizabeth G; Malik, Rainer; Sudlow, Cathie; Rothwell, Peter M; Maguire, Jane M et al. (Lippincott Williams & Wilkins, 2015-10-06)
      Background and Purpose: Evidence from epidemiological studies points to differences in factors predisposing to stroke by age and sex. Whether these arise due to different genetic influences remained untested. Here, we use ...
    • Genetic variation at 16q24.2 is associated with small vessel stroke. 

      Traylor, Matthew Stephen; Malik, Rainer; Nalls, Mike A; Cotlarciuc, Ioana; Radmanesh, Farid; Thorleifsson, Gudmar; Hanscombe, Ken B et al. (Wiley, 2017-03)
      OBJECTIVE: Genome-wide association studies (GWAS) have been successful at identifying associations with stroke and stroke subtypes, but have not yet identified any associations solely with small vessel stroke (SVS). SVS ...
    • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 

      Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew Stephen; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes Carola et al. (Springer Nature, 2018-04)
      Stroke has multiple etiologies but the underlying genes and pathways are largely unknown. We conducted a multi-ancestry genome-wide association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and ...
    • Pharmacogenetic testing through the direct-to-consumer genetic testing company 23andMe 

      Lu, Mengfei; Lewis, Cathryn M; Traylor, Matthew (2017-06-19)
      Abstract Background Rapid advances in scientific research have led to an increase in public awareness of genetic testing and pharmacogenetics. Direct-to-consumer ...
    • Shared genetic contribution to Ischaemic Stroke and Alzheimer’s Disease 

      Traylor, Matthew Stephen; Adib-Samii, Poneh; Harold, Denise; Dichgans, Martin; Williams, Julie; Lewis, Cathryn M; Markus, Hugh Stephen (Wiley, 2016-03-30)
      Objective Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and ischemic stroke (IS). We investigated the evidence that shared genetic factors underpin the two ...
    • Trial Protocol: Communicating DNA-based risk assessments for Crohn's disease: a randomised controlled trial assessing impact upon stopping smoking 

      Whitwell, Sophia CL; Mathew, Christopher G; Lewis, Cathryn M; Forbes, Alastair; Watts, Sally; Sanderson, Jeremy; Hollands, Gareth John et al. (2011-01-19)
      Abstract Background Estimates of the risk of developing Crohn's disease (CD) can be made using DNA testing for mutations in the NOD2 (CARD15) gene, family history, and smoking status. Smoking doubles the risk of CD, a risk ...