Now showing items 1-20 of 73

    • Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors 

      Naguib, Adam; Cooke, James C; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J; Luben, Robert; Ball, Richard Y et al. (2011-04-07)
      Abstract Background The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study ...
    • Area deprivation and age related macular degeneration in the EPIC Norfolk Eye Study 

      Yip, Jennifer LY; Khawaja, Anthony P; Chan, Michelle PY; Broadway, David C; Peto, Tunde; Luben, Robert; Hayat, Shabina Anwar et al. (Elsevier, 2015-02-14)
      Objectives: To investigate the relationship between area deprivation, individual socioeconomic status (SES) and age related macular degeneration (AMD). Study Design: Cross sectional study nested within a longitudinal cohort ...
    • The association between a biomarker score for fruit and vegetable intake and incident type 2 diabetes: the EPIC-Norfolk study 

      Cooper, Andrew John; Sharp, Stephen John; Luben, Robert; Khaw, Kay-Tee; Wareham, Nicholas John; Forouhi, Nita Gandhi (Nature Publishing Group, 2014)
      Background/Objectives: Biomarkers for a mixed fruit and vegetable (FV) diet are needed to provide a better understanding of the association between FV intake and type 2 diabetes. We aimed to examine the prospective association ...
    • Association between intake of less-healthy foods defined by the United Kingdom's nutrient profile model and cardiovascular disease: A population-based cohort study. 

      Mytton, Oliver Tristan; Forouhi, Nita Gandhi; Scarborough, Peter; Lentjes, Maria Antonetta; Luben, Robert; Rayner, Mike; Khaw, Kay-Tee et al. (Public Library of Science (PLoS), 2018-01-04)
      Abstract Background: In the UK the FSA-Ofcom nutrient profiling model is used to define less-healthy foods that cannot be advertised to children. However there has been limited investigation of whether less-healthy foods ...
    • Association of genetic susceptibility variants for type 2 diabetes with breast cancer risk in women of European ancestry 

      Zhao, Zhiguo; Wen, Wanqing; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Zhang, Ben; Long, Jirong et al. (Springer, 2016-04-06)
      Purpose Type 2 diabetes (T2D) has been reported to be associated with an elevated risk of breast cancer. It is unclear, however, whether this association is due to shared genetic factors. Methods We constructed a genetic ...
    • Associations with intraocular pressure across Europe: The European Eye Epidemiology (E$^3$) Consortium 

      Khawaja, Anthony P; Springelkamp, Henriët; Creuzot-Garcher, Catherine; Delcourt, Cécile; Hofman, Albert; Höhn, René; Iglesias, Adriana I et al. (Springer, 2016-09-09)
      Raised intraocular pressure (IOP) is the most important risk factor for developing glaucoma, the second commonest cause of blindness globally. Understanding associations with IOP and variations in IOP between countries may ...
    • Baseline anticholinergic burden from medications predicts incident fatal and non-fatal stroke in the EPIC-Norfolk general population. 

      Gamble, David T; Clark, Allan B; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee; Myint, Phyo K (OUP, 2018-04)
      Abstract Background: Stroke is primarily a disease of older age with a substantial impact on global mortality and morbidity. Whilst medications with anticholinergic effects are widely used, no studies have been conducted ...
    • Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk study 

      Ward, Heather Anne; Chapelais, Gaelle; Kuhnle, Gunter GC; Luben, Robert; Khaw, Kay-Tee; Bingham, Sheila (2008-04-17)
      Abstract Introduction Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential ...
    • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 

      Dunning, Alison Margaret; Michailidou, Kyriaki; Kuchenbaecker, Karoline Bernhardine; Thompson, Deborah Jane; French, Juliet D; Beesley, Jonathan; Healey, Catherine S et al. (Nature Publishing Group, 2016)
      We analysed 3872 common genetic variants across the ESR1 locus (encoding estrogen receptor–alpha) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, ...
    • Carotenoid dietary intakes and plasma concentrations are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the European Prospective Investigation into Cancer and Nutrition (EPIC)-Norfolk cohort 

      Hayhoe, RPG; Lentjes, Maria Antonetta; Mulligan, Angela Assumpta; Luben, Robert; Khaw, Kay-Tee; Welch, AA (Cambridge University Press, 2017-05-28)
      Carotenoids are found in abundance in fruit and vegetables, and may be involved in the positive association of these foods with bone health. This study aimed to explore the associations of dietary carotenoid intakes and ...
    • Cod liver oil supplement consumption and health: cross-sectional results from the EPIC-Norfolk cohort study 

      Lentjes, Maria Antonetta; Welch, Ailsa A; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (MDPI, 2014-10-16)
      Supplement users (SU) make healthy lifestyle choices; on the other hand, SU report more medical conditions. We hypothesised that cod liver oil (CLO) consumers are similar to non-supplement users, since CLO use might originate ...
    • Cognitive function in a general population of men and women: a cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk) 

      Hayat, Shabina Anwar; Luben, Robert; Moore, Stephanie; Dalzell, Nichola Jane; Bhaniani, Amit; Anuj, Serena; Matthews, Fiona E et al. (BioMed Central, 2014-12-19)
      $\textbf{Background:}$ Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. $ ...
    • Common variants in the ATM, BRCA1, BRCA2, CHEK2 & TP53 cancer susceptibility genes are unlikely to increase breast cancer risk 

      Baynes, Caroline; Healey, Catherine S; Pooley, Karen Anne; Scollen, Serena A; Luben, Robert; Thompson, Deborah Jane; Pharoah, Paul David et al. (2007-04-11)
      Abstract Introduction Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the ...
    • Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs 

      Benusiglio, Patrick R; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison Margaret et al. (2005-07-19)
      Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast ...
    • A comprehensive evaluation of interaction between genetic variants and use of menopausal hormone therapy on mammographic density 

      Rudolph, A; Fasching, PA; Behrens, S; Eilber, U; Bolla, Manjeet Kaur; Wang, Qin; Thompson, Deborah Jane et al. (BioMed Central, 2015-08-16)
      Introduction: Mammographic density is an established breast cancer risk factor with a strong genetic component and can be increased in women using menopausal hormone therapy (MHT). Here, we aimed to identify genetic variants ...
    • Contribution of cod liver oil-related nutrients (vitamins A, D, E and eicosapentaenoic acid and docosahexaenoic acid) to daily nutrient intake and their associations with plasma concentrations in the EPIC-Norfolk cohort 

      Lentjes, Maria Antonetta; Mulligan, Angela Assumpta; Welch, Ailsa A; Bhaniani, Amit; Luben, Robert; Khaw, Kay-Tee (Wiley on behalf of the British Dietetic Association, 2014-09-16)
      Background: Total Nutrient Intake (TNI) is intake from food and supplements. This provides assessment of nutrient adequacy, prevalence of excessive intake as well as response on biomarkers. Cod liver oil (CLO) is the most ...
    • Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study. 

      Winkler, Thomas W; Justice, Anne E; Graff, Mariaelisa; Barata, Llilda; Feitosa, Mary F; Chu, Su; Czajkowski, Jacek et al. (2016-06-29)
    • Cross sectional and longitudinal associations between cardiovascular risk factors and age related macular degeneration in the EPIC-Norfolk Eye study. 

      Yip, Jennifer LY; Khawaja, Anthony P; Chan, Michelle PY; Broadway, David C; Peto, Tunde; Tufail, Adnan; Luben, Robert et al. (PLoS, 2015-07-15)
      Purpose: To examine the cross sectional and longitudinal relationship between cardiovascular risk factors and age-related macular degeneration (AMD) in a large British cohort study. Methods: The EPIC Norfolk Eye study ...
    • Cross Sectional Associations between Socio-Demographic Factors and Cognitive Performance in an Older British Population: The European Investigation of Cancer in Norfolk (EPIC-Norfolk) Study 

      Hayat, Shabina Anwar; Luben, Robert; Dalzell, Nichola Jane; Moore, S; Anuj, S; Matthews, Fiona Elaine; Wareham, Nicholas John et al. (PLoS ONE, 2016-12-08)
      $\textbf{BACKGROUND}$: Cognition covers a range of abilities, such as memory, response time and language, with tests assessing either specific or generic aspects. However differences between measures may be observed within ...
    • Cross-Sectional Associations between Different Measures of Obesity and Muscle Strength in Men and Women in a British Cohort Study 

      Keevil, Victoria Louise; Luben, Robert; Dalzell, Nichola Jane; Hayat, Shabina Anwar; Sayer, Avan Aihie; Wareham, Nicholas John; Khaw, Kay-Tee (Springer, 2014-09-04)
      Objectives: The relationship between obesity and grip strength, a key indicator of sarcopenia, has been inconsistently reported. We aimed to examine associations between grip strength and both body mass index (BMI), a ...