Now showing items 1-20 of 22

    • Alterations in PTEN and PIK3CA in colorectal cancers in the EPIC Norfolk study: associations with clinicopathological and dietary factors 

      Naguib, Adam; Cooke, James C.; Happerfield, Lisa; Kerr, Lucy; Gay, Laura J.; Luben, Robert; Ball, Richard Y. et al. (2011-04-07)
      Abstract Background The PTEN tumour suppressor gene and PIK3CA proto-oncogene encode proteins which contribute to regulation and propagation of signal transduction through the PI3K/AKT signalling pathway. This study ...
    • Area deprivation and age related macular degeneration in the EPIC Norfolk Eye Study 

      Yip, Jennifer L. Y.; Khawaja, Anthony P.; Chan, Michelle P. Y.; Broadway, David C.; Peto, Tunde; Luben, Robert; Hayat, Shabina et al. (Elsevier, 2015-02-14)
      Objectives: To investigate the relationship between area deprivation, individual socioeconomic status (SES) and age related macular degeneration (AMD). Study Design: Cross sectional study nested within a longitudinal ...
    • Breast cancer risk in relation to urinary and serum biomarkers of phytoestrogen exposure in the EPIC-Norfolk study 

      Ward, Heather A.; Chapelais, Gaelle; Kuhnle, Gunter G. C.; Luben, Robert; Khaw, Kay-Tee; Bingham, Sheila (2008-04-17)
      Abstract Introduction Phytoestrogens are a group of compounds found in plants that structurally resemble the hormone oestradiol, and thus have the potential to act as oestrogen agonists or antagonists. Their potential ...
    • Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170 

      Dunning, Alison M.; Michailidou, Kyriaki; Kuchenbaecker, Karoline B.; Thompson, Deborah; French, Juliet D.; Beesley, Jonathan; Healey, Catherine S. et al. (Nature Publishing Group, 2016)
      We analysed 3872 common genetic variants across the ESR1 locus (encoding estrogen receptor–alpha) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, ...
    • Cognitive function in a general population of men and women: A cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk) 

      Hayat, Shabina A.; Luben, Robert; Moore, Stephanie; Dalzell, Nichola; Bhaniani, Amit; Anuj, Serena; Matthews, Fiona E. et al. (BioMed Central, 2014-12-19)
      Background: Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. Objective: We ...
    • Common variants in the ATM, BRCA1, BRCA2, CHEK2 & TP53 cancer susceptibility genes are unlikely to increase breast cancer risk 

      Baynes, Caroline; Healey, Catherine S.; Pooley, Karen A.; Scollen, Serena A.; Luben, Robert; Thompson, Deborah J.; Pharoah, Paul D. P. et al. (2007-04-11)
      Abstract Introduction Certain rare, familial mutations in the ATM, BRCA1, BRCA2, CHEK2 or TP53 genes increase susceptibility to breast cancer but it has not, until now, been clear whether common polymorphic variants in the ...
    • Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs 

      Benusiglio, Patrick R.; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison M. et al. (2005-07-19)
      Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast ...
    • Cross sectional and longitudinal associations between cardiovascular risk factors and age related macular degeneration in the EPIC-Norfolk Eye study. 

      Yip, Jennifer L. Y.; Khawaja, Anthony P.; Chan, Michelle P. Y.; Broadway, David C.; Peto, Tunde; Tufail, Adnan; Luben, Robert et al. (PLoS, 2015-07-15)
      Purpose: To examine the cross sectional and longitudinal relationship between cardiovascular risk factors and age-related macular degeneration (AMD) in a large British cohort study. Methods: The EPIC Norfolk Eye study ...
    • Cross-Sectional Associations between Different Measures of Obesity and Muscle Strength in Men and Women in a British Cohort Study 

      Keevil, Victoria L.; Luben, Robert; Dalzell, Nichola; Hayat, Shabina; Sayer, Avan Aihie; Wareham, Nicholas J.; Khaw, Kay-Tee (Springer, 2014-09-04)
      Objectives: The relationship between obesity and grip strength, a key indicator of sarcopenia, has been inconsistently reported. We aimed to examine associations between grip strength and both body mass index (BMI), a ...
    • CYP19A1 fine-mapping and Mendelian randomization: estradiol is causal for endometrial cancer. 

      Thompson, Deborah J.; O’Mara, Tracy A.; Glubb, Dylan M.; Painter, Jodie N.; Cheng, Timothy; Folkerd, Elizabeth; Doody, Deborah et al. (Bioscientifica, 2015-11-16)
      Candidate gene studies have reported CYP19A1 variants to be associated with endometrial cancer and with estradiol concentrations. We analysed 2,937 SNPs in 6,608 endometrial cancer cases and 37,925 controls and report the ...
    • Daytime napping, sleep duration and serum C-reactive protein: a population-based cohort study 

      Leng, Yue; Ahmadi-Abhari, Sara; Wainwright, Nick W. J.; Cappuccio, Francesco P.; Surtees, Paul G.; Luben, Robert; Brayne, Carol et al. (BMJ Group, 2014-11-11)
      Objectives: To explore whether daytime napping and sleep duration are linked to serum C-reactive protein (CRP), a pro-inflammatory marker, in an older-aged British population. Design: Cross-sectional study Setting: ...
    • Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study 

      Naguib, Adam; Mitrou, Panagiota N.; Gay, Laura J.; Cooke, James C.; Luben, Robert; Ball, Richard Y.; McTaggart, Alison et al. (2010-03-16)
      Abstract Background BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations ...
    • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation 

      Ghoussaini, Maya; Edwards, Stacey L.; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha et al. (NPG, 2014-09-23)
      GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine-mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the “iCOGS” genotyping ...
    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium 

      Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya et al. (Oxford Journals, 2014-01-14)
      Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x-ray (DXA), may be convenient alternatives for evaluating ...
    • Greater accordance with the DASH dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 

      Monsivais, Pablo; Scarborough, Peter; Lloyd, Tina; Mizdrak, Anja; Luben, Robert; Mulligan, Angela A.; Wareham, Nicholas J. et al. (American Society for Nutrition, 2015-04-29)
      Background: The Dietary Approaches to Stop Hypertension (DASH) diet is a proven way to prevent and control hypertension and other chronic disease. Because the DASH diet emphasizes plant-based foods, including vegetables ...
    • Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements 

      Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Luben, Robert; Khaw, Kay-Tee; Silman, Alan J; Symmons, Deborah PM et al. (2012-07-26)
      AbstractBackgroundThere are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS ...
    • Objective sedentary time, MVPA and physical capability in a British cohort 

      Keevil, Victoria L.; Cooper, Andrew J. M.; Wijndaele, Katrien; Luben, Robert; Wareham, Nicholas J.; Brage, Søren; Khaw, Kay-Tee (Wolters Kluwer, 2015)
      Purpose: Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time with physical functional health independent of time spent in ...
    • Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression 

      Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith et al. (Elsevier, 2015-06-11)
      Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association ...
    • Retinal nerve fibre layer measures and cognitive function in the EPIC-Norfolk Cohort Study 

      Khawaja, Anthony P.; Chan, Michelle P. Y.; Yip, Jennifer L. Y.; Broadway, David C.; Garway-Heath, David F.; Luben, Robert; Hayat, Shabina et al. (Association for Research in Vision and Ophthalmology, 2016)
      Purpose: To examine the relationship between retinal nerve fibre layer (RNFL) thickness and cognitive function in a population of older British adults. Methods: Participants of the European Prospective Investigation of ...
    • Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort 

      Ishihara, Lianna S.; Khaw, Kay-Tee; Luben, Robert; Bingham, Sheila; Welch, Ailsa; Day, Nicholas E.; Brayne, Carol (2005-08-24)
      Abstract Background Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential ...