Now showing items 23-42 of 72

    • Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor? 

      Leng, Yue; Wainwright, Nick WJ; Cappuccio, Francesco P; Surtees, Paul G; Hayat, Shabina Anwar; Luben, Robert; Brayne, Carol Elspeth et al. (Elsevier, 2016-07-12)
      $\textit{Background:}$ We have identified a strong association between daytime napping and increased mortality risk from respiratory diseases, but little is known about the relationship between daytime napping and respiratory ...
    • Daytime napping, sleep duration and increased 8-year risk of type 2 diabetes in a British population 

      Leng, Y; Cappuccio, FP; Surtees, PG; Luben, Robert; Brayne, Carol Elspeth; Khaw, Kay-Tee (Elsevier, 2016-06-28)
      Background and aims Few studies have prospectively examined the relationship between daytime napping and risk of type 2 diabetes. We aimed to study the effects of daytime napping and the joint effects of napping and sleep ...
    • Daytime napping, sleep duration and serum C-reactive protein: a population-based cohort study 

      Leng, Yue; Ahmadi-Abhari, Sara; Wainwright, Nick WJ; Cappuccio, Francesco P; Surtees, Paul G; Luben, Robert; Brayne, Carol Elspeth et al. (BMJ Group, 2014-11-11)
      $\textbf{Objectives:}$ To explore whether daytime napping and sleep duration are linked to serum C reactive protein (CRP), a pro-inflammatory marker, in an older aged British population. $\textbf{Design:}$ Cross-sectional ...
    • The descriptive epidemiology of accelerometer-measured physical activity in older adults 

      Berkemeyer, Katrin; Wijndaele, Katrien Lieve; White, Tom; Cooper, Andrew John; Luben, Robert; Westgate, Kathryn Louise; Griffin, Simon James et al. (BioMed Central, 2016-01-07)
      Background: Objectively measured physical activity between older individuals and between populations has been poorly described. We aimed to describe and compare the variation in accelerometry data in older UK (EPIC-Norfolk) ...
    • Dietary magnesium and potassium intakes and circulating magnesium are associated with heel bone ultrasound attenuation and osteoporotic fracture risk in the EPIC-Norfolk cohort study 

      Hayhoe, Richard PG; Lentjes, Maria Antonetta; Luben, Robert; Khaw, Kay-Tee; Welch, Ailsa A (American Society for Nutrition, 2015-06-18)
      Background: In our ageing population, maintenance of bone health is critical to reduce the risk of osteoporosis and potentially debilitating consequences of fractures in older individuals. Amongst modifiable lifestyle and ...
    • Dietary Polyphenols in the Aetiology of Crohn's Disease and Ulcerative Colitis—A Multicenter European Prospective Cohort Study (EPIC) 

      Lu, Yunxia; Zamora-Ros, Raul; Chan, Simon; Cross, Amanda J; Ward, Heather; Jakszyn, Paula; Luben, Robert et al. (Oxford University Press, 2017-12-01)
      Background: Oxidative stress may be involved in the aetiology of inflammatory bowel disease and whether dietary polyphenols, which possess antioxidants properties, prevent its development is unknown. Methods: A total ...
    • Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study 

      Naguib, Adam; Mitrou, Panagiota N; Gay, Laura J; Cooke, James C; Luben, Robert; Ball, Richard Y; McTaggart, Alison et al. (2010-03-16)
      Abstract Background BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations ...
    • Dog ownership supports the maintenance of physical activity during poor weather in older English adults: cross-sectional results from the EPIC Norfolk cohort 

      Wu, Y-T; Luben, Robert; Jones, Andy (British Medical Association, 2017-08-08)
      BACKGROUND: Dog ownership has been suggested to encourage physical activity in older adults and may enhance resilience to poor environmental conditions. This study investigates the role of dog ownership and walking as a ...
    • Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (Springer Nature, 2017-11-07)
      A correction to this article has been published and is linked from the HTML version of this article.
    • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation 

      Ghoussaini, Maya; Edwards, Stacey L; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha et al. (NPG, 2014-09-23)
      GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine-mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the “iCOGS” genotyping ...
    • Flavonoid Intake in European Adults (18 to 64 Years) 

      Vogiatzoglou, Anna; Mulligan, Angela Assumpta; Lentjes, Maria Antonetta; Luben, Robert; Spencer, Jeremy PE; Schroeter, Hagen; Khaw, Kay-Tee et al. (PLOS, 2015-05-26)
      Background Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and intervention studies have shown that many flavonoids are ...
    • Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study. 

      Julian, C; Lentjes, Maria Antonetta; Huybrechts, I; Luben, Robert; Wareham, Nicholas John; Moreno, LA; Khaw, Kay-Tee (PLOS, 2016-11-23)
      Vitamin D deficiency and physical inactivity have been associated with bone loss and fractures, but their combined effect has scarcely been studied either in younger or older adults. Therefore, we aimed to assess the ...
    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium 

      Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya et al. (Oxford Journals, 2014-01-14)
      Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x-ray (DXA), may be convenient alternatives for evaluating ...
    • Genetic modifiers of CHEK2*1100delC-associated breast cancer risk 

      Muranen, Taru A; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno et al. (Nature Publishing Group, 2016-10-06)
      Purpose: CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo, Yan; Andersen, Shaneda Warren; Shu, Xiao-Ou; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Garcia-Closas, Montserrat et al. (Public Library of Science, 2016-08-23)
      $\textbf{Background}$ Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal ...
    • Genome-wide analysis identifies 12 loci influencing human reproductive behavior. 

      Barban, N; Jansen, R; de Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X et al. (Nature Publishing Group, 2016-10-31)
      The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric ...
    • Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels 

      Zhang, W; Jernerén, F; Lehne, BC; Chen, M-H; Luben, Robert; Johnston, C; Elshorbagy, A et al. (Schattauer, 2016-11-30)
      L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. ...
    • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

      Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L et al. (Nature Publishing Group, 2017-04-26)
      Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 

      Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L; Feitosa, Mary F; Barata, Llilda; Winkler, Thomas W et al. (2017-04-27)
    • Greater accordance with the DASH dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 

      Monsivais, Pablo; Scarborough, Peter; Lloyd, Tina; Mizdrak, Anja; Luben, Robert; Mulligan, Angela Assumpta; Wareham, Nicholas John et al. (American Society for Nutrition, 2015-04-29)
      Background: The Dietary Approaches to Stop Hypertension (DASH) diet is a proven way to prevent and control hypertension and other chronic disease. Because the DASH diet emphasizes plant-based foods, including vegetables ...