Now showing items 12-25 of 25

    • Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor? 

      Leng, Yue; Wainwright, Nick W. J.; Cappuccio, Francesco P.; Surtees, Paul G.; Hayat, Shabina; Luben, Robert; Brayne, Carol et al. (Elsevier, 2016-07-12)
      $\textit{Background:}$ We have identified a strong association between daytime napping and increased mortality risk from respiratory diseases, but little is known about the relationship between daytime napping and respiratory ...
    • Daytime napping, sleep duration and serum C-reactive protein: a population-based cohort study 

      Leng, Yue; Ahmadi-Abhari, Sara; Wainwright, Nick W. J.; Cappuccio, Francesco P.; Surtees, Paul G.; Luben, Robert; Brayne, Carol et al. (BMJ Group, 2014-11-11)
      Objectives: To explore whether daytime napping and sleep duration are linked to serum C-reactive protein (CRP), a pro-inflammatory marker, in an older-aged British population. Design: Cross-sectional study Setting: ...
    • Dietary, lifestyle and clinicopathological factors associated with BRAF and K-ras mutations arising in distinct subsets of colorectal cancers in the EPIC Norfolk study 

      Naguib, Adam; Mitrou, Panagiota N.; Gay, Laura J.; Cooke, James C.; Luben, Robert; Ball, Richard Y.; McTaggart, Alison et al. (2010-03-16)
      Abstract Background BRAF and K-ras proto-oncogenes encode components of the ERK signalling pathway and are frequently mutated in colorectal cancer. This study investigates the associations between BRAF and K-ras mutations ...
    • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation 

      Ghoussaini, Maya; Edwards, Stacey L.; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha et al. (NPG, 2014-09-23)
      GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine-mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the “iCOGS” genotyping ...
    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium 

      Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya et al. (Oxford Journals, 2014-01-14)
      Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x-ray (DXA), may be convenient alternatives for evaluating ...
    • Greater accordance with the DASH dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 

      Monsivais, Pablo; Scarborough, Peter; Lloyd, Tina; Mizdrak, Anja; Luben, Robert; Mulligan, Angela A.; Wareham, Nicholas J. et al. (American Society for Nutrition, 2015-04-29)
      Background: The Dietary Approaches to Stop Hypertension (DASH) diet is a proven way to prevent and control hypertension and other chronic disease. Because the DASH diet emphasizes plant-based foods, including vegetables ...
    • Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements 

      Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Luben, Robert; Khaw, Kay-Tee; Silman, Alan J; Symmons, Deborah PM et al. (2012-07-26)
      AbstractBackgroundThere are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS ...
    • Objective sedentary time, MVPA and physical capability in a British cohort 

      Keevil, Victoria L.; Cooper, Andrew J. M.; Wijndaele, Katrien; Luben, Robert; Wareham, Nicholas J.; Brage, Søren; Khaw, Kay-Tee (Wolters Kluwer, 2015)
      Purpose: Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time with physical functional health independent of time spent in ...
    • Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression 

      Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith et al. (Elsevier, 2015-06-11)
      Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association ...
    • Retinal nerve fibre layer measures and cognitive function in the EPIC-Norfolk Cohort Study 

      Khawaja, Anthony P.; Chan, Michelle P. Y.; Yip, Jennifer L. Y.; Broadway, David C.; Garway-Heath, David F.; Luben, Robert; Hayat, Shabina et al. (Association for Research in Vision and Ophthalmology, 2016)
      Purpose: To examine the relationship between retinal nerve fibre layer (RNFL) thickness and cognitive function in a population of older British adults. Methods: Participants of the European Prospective Investigation of ...
    • Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort 

      Ishihara, Lianna S.; Khaw, Kay-Tee; Luben, Robert; Bingham, Sheila; Welch, Ailsa; Day, Nicholas E.; Brayne, Carol (2005-08-24)
      Abstract Background Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential ...
    • Smoking and high-risk mammographic parenchymal patterns: a case-control study 

      Sala, Evis; Warren, Ruth M. L.; McCann, Jenny; Duffy, Stephen; Luben, Robert; Day, Nicholas E. (1999-11-16)
      Statement of findings Current smoking was strongly and inversely associated with high-risk patterns, after adjustment for concomitant risk factors. Relative to never smokers, current smokers were significantly less likely ...
    • Television Viewing, Walking Speed and Grip Strength in a Prospective Cohort Study 

      Keevil, Victoria L.; Wijndaele, Katrien; Luben, Robert; Sayer, Avan A.; Wareham, Nicholas J.; Khaw, Kay-Tee (2014-07-18)
      Purpose Television (TV) watching is the most prevalent sedentary leisure-time activity in the United Kingdom. We examined associations between TV viewing time, measured over 10 years, and two objective measures of ...
    • Topical Beta-blockers and Cardiovascular Mortality: Systematic review and meta-analysis with data from the EPIC-Norfolk cohort study 

      Pinnock, Claude; Yip, Jennifer L. Y.; Khawaja, Anthony P.; Luben, Robert; Hayat, Shabina; Broadway, David C.; Foster, Paul J. et al. (Taylor & Francis, 2016)
      ${\bf Purpose:}$ To determine if topical beta-blocker use is associated with increased cardiovascular mortality, particularly amongst people with self reported glaucoma. ${\bf Methods:}$ All participants who participated ...