Now showing items 31-50 of 73

    • Erratum: Large meta-analysis of genome-wide association studies identifies five loci for lean body mass 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (Springer Nature, 2017-11-07)
      A correction to this article has been published and is linked from the HTML version of this article.
    • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation 

      Ghoussaini, Maya; Edwards, Stacey L; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha et al. (NPG, 2014-09-23)
      GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine-mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the “iCOGS” genotyping ...
    • Flavonoid Intake in European Adults (18 to 64 Years) 

      Vogiatzoglou, Anna; Mulligan, Angela Assumpta; Lentjes, Maria Antonetta; Luben, Robert; Spencer, Jeremy PE; Schroeter, Hagen; Khaw, Kay-Tee et al. (PLOS, 2015-05-26)
      Background Flavonoids are a group of phenolic secondary plant metabolites that are ubiquitous in plant-based diets. Data from anthropological, observational and intervention studies have shown that many flavonoids are ...
    • Fracture Risk in Relation to Serum 25-Hydroxyvitamin D and Physical Activity: Results from the EPIC-Norfolk Cohort Study. 

      Julian, C; Lentjes, Maria Antonetta; Huybrechts, I; Luben, Robert; Wareham, Nicholas John; Moreno, LA; Khaw, Kay-Tee (PLOS, 2016-11-23)
      Vitamin D deficiency and physical inactivity have been associated with bone loss and fractures, but their combined effect has scarcely been studied either in younger or older adults. Therefore, we aimed to assess the ...
    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium 

      Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya et al. (Oxford Journals, 2014-01-14)
      Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x-ray (DXA), may be convenient alternatives for evaluating ...
    • Genetic modifiers of CHEK2*1100delC-associated breast cancer risk 

      Muranen, Taru A; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno et al. (Nature Publishing Group, 2016-10-06)
      Purpose: CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo, Yan; Andersen, Shaneda Warren; Shu, Xiao-Ou; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Garcia-Closas, Montserrat et al. (Public Library of Science, 2016-08-23)
      $\textbf{Background}$ Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal ...
    • Genome-wide analysis identifies 12 loci influencing human reproductive behavior. 

      Barban, N; Jansen, R; de Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X et al. (Nature Publishing Group, 2016-10-31)
      The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric ...
    • Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels 

      Zhang, W; Jernerén, F; Lehne, BC; Chen, M-H; Luben, Robert; Johnston, C; Elshorbagy, A et al. (Schattauer, 2016-11-30)
      L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. ...
    • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

      Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L et al. (Nature Publishing Group, 2017-04-26)
      Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 

      Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L; Feitosa, Mary F; Barata, Llilda; Winkler, Thomas W et al. (2017-04-27)
    • Greater accordance with the DASH dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 

      Monsivais, Pablo; Scarborough, Peter; Lloyd, Tina; Mizdrak, Anja; Luben, Robert; Mulligan, Angela Assumpta; Wareham, Nicholas John et al. (American Society for Nutrition, 2015-04-29)
      Background: The Dietary Approaches to Stop Hypertension (DASH) diet is a proven way to prevent and control hypertension and other chronic disease. Because the DASH diet emphasizes plant-based foods, including vegetables ...
    • Habitual chocolate consumption and the risk of incident heart failure among healthy men and women 

      Kwok, Chun Shing; Loke, Yoon K; Welch, Ailsa A; Luben, Robert; Lentjes, Maria Antonetta; Boekholdt, S Matthijs; Pfister, Roman et al. (Elsevier, 2016-01-28)
      Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. ...
    • Ideal cardiovascular health and risk of cardiovascular events in the EPIC-Norfolk prospective population study 

      Lachman, Sangeeta; Peters, Ron JG; Lentjes, Maria Antonetta; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee et al. (SAGE, 2015-09-02)
      Background The American Heart Association (AHA) has prioritized seven cardiovascular health metrics to reduce the cardiovascular burden, including: body mass index, healthy diet, physical activity, smoking status, blood ...
    • Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults: EPIC Norfolk prospective population study. 

      Lachman, Sangeeta; Boekholdt, S Matthijs; Luben, Robert; Sharp, Stephen John; Brage, Soren; Khaw, Kay-Tee; Peters, Ron Jg et al. (SAGE, 2018-01)
      Abstract Background: There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether ...
    • Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements 

      Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Luben, Robert; Khaw, Kay-Tee; Silman, Alan J; Symmons, Deborah PM et al. (2012-07-26)
      AbstractBackgroundThere are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS ...
    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (2017-07-19)
    • Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study 

      Ahmadi-Abhari, Sara; Kaptoge, Stephen Kipkemoi; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BioMed Central, 2015-05-22)
      Background: Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large ...
    • Longitudinal associations between marine omega-3 supplement users and Coronary Heart Disease in a UK population-based cohort 

      Lentjes, Maria Antonetta; Keogh, RH; Welch, AA; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Journals, 2017-10-01)
      Objectives: Assess the association between marine omega-3 polyunsaturated fatty acid (n 3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. Design: Prospective cohort study, ...
    • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing 

      Easton, Douglas Frederick; Lesueur, Fabienne; Decker, Brennan; Michailidou, Kyriaki; Li, Jun; Allen, Jamie; Luccarini, Craig et al. (BMJ Group, 2016-02-26)
      Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and ...