Now showing items 35-54 of 72

    • Genetic determinants of heel bone properties: Genome-wide association meta-analysis and replication in the GEFOS/GENOMOS consortium 

      Moayyeri, Alireza; Hsu, Yi-Hsiang; Karasik, David; Estrada, Karol; Xiao, Su-Mei; Nielson, Carrie; Srikanth, Priya et al. (Oxford Journals, 2014-01-14)
      Quantitative ultrasound of the heel captures heel bone properties that independently predict fracture risk and, with bone mineral density (BMD) assessed by x-ray (DXA), may be convenient alternatives for evaluating ...
    • Genetic modifiers of CHEK2*1100delC-associated breast cancer risk 

      Muranen, Taru A; Greco, Dario; Blomqvist, Carl; Aittomäki, Kristiina; Khan, Sofia; Hogervorst, Frans; Verhoef, Senno et al. (Nature Publishing Group, 2016-10-06)
      Purpose: CHEK2*1100delC is a founder variant in European populations that confers a two- to threefold increased risk of breast cancer (BC). Epidemiologic and family studies have suggested that the risk associated with ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent 

      Guo, Yan; Andersen, Shaneda Warren; Shu, Xiao-Ou; Michailidou, Kyriaki; Bolla, Manjeet K; Wang, Qin; Garcia-Closas, Montserrat et al. (Public Library of Science, 2016-08-23)
      $\textbf{Background}$ Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal ...
    • Genome-wide analysis identifies 12 loci influencing human reproductive behavior. 

      Barban, N; Jansen, R; de Vlaming, R; Vaez, A; Mandemakers, JJ; Tropf, FC; Shen, X et al. (Nature Publishing Group, 2016-10-31)
      The genetic architecture of human reproductive behavior-age at first birth (AFB) and number of children ever born (NEB)-has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric ...
    • Genome-wide association reveals that common genetic variation in the kallikrein-kinin system is associated with serum L-arginine levels 

      Zhang, W; Jernerén, F; Lehne, BC; Chen, M-H; Luben, Robert; Johnston, C; Elshorbagy, A et al. (Schattauer, 2016-11-30)
      L-arginine is the essential precursor of nitric oxide, and is involved in multiple key physiological processes, including vascular and immune function. The genetic regulation of blood L-arginine levels is largely unknown. ...
    • Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits 

      Justice, AE; Winkler, TW; Feitosa, MF; Graff, M; Fisher, VA; Young, K; Barata, L et al. (Nature Publishing Group, 2017-04-26)
      Few genome-wide association studies (GWAS) account for environmental exposures, like smoking, potentially impacting the overall trait variance when investigating the genetic contribution to obesity-related traits. Here, ...
    • Genome-wide physical activity interactions in adiposity - A meta-analysis of 200,452 adults. 

      Graff, Mariaelisa; Scott, Robert A; Justice, Anne E; Young, Kristin L; Feitosa, Mary F; Barata, Llilda; Winkler, Thomas W et al. (2017-04-27)
    • Greater accordance with the DASH dietary pattern is associated with lower diet-related greenhouse gas production but higher dietary costs in the United Kingdom 

      Monsivais, Pablo; Scarborough, Peter; Lloyd, Tina; Mizdrak, Anja; Luben, Robert; Mulligan, Angela Assumpta; Wareham, Nicholas John et al. (American Society for Nutrition, 2015-04-29)
      Background: The Dietary Approaches to Stop Hypertension (DASH) diet is a proven way to prevent and control hypertension and other chronic disease. Because the DASH diet emphasizes plant-based foods, including vegetables ...
    • Habitual chocolate consumption and the risk of incident heart failure among healthy men and women 

      Kwok, Chun Shing; Loke, Yoon K; Welch, Ailsa A; Luben, Robert; Lentjes, Maria Antonetta; Boekholdt, S Matthijs; Pfister, Roman et al. (Elsevier, 2016-01-28)
      Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. ...
    • Ideal cardiovascular health and risk of cardiovascular events in the EPIC-Norfolk prospective population study 

      Lachman, Sangeeta; Peters, Ron JG; Lentjes, Maria Antonetta; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee et al. (SAGE, 2015-09-02)
      Background The American Heart Association (AHA) has prioritized seven cardiovascular health metrics to reduce the cardiovascular burden, including: body mass index, healthy diet, physical activity, smoking status, blood ...
    • Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults: EPIC Norfolk prospective population study. 

      Lachman, Sangeeta; Boekholdt, S Matthijs; Luben, Robert; Sharp, Stephen John; Brage, Soren; Khaw, Kay-Tee; Peters, Ron Jg et al. (SAGE, 2018-01)
      Abstract Background: There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether ...
    • Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements 

      Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Luben, Robert; Khaw, Kay-Tee; Silman, Alan J; Symmons, Deborah PM et al. (2012-07-26)
      AbstractBackgroundThere are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS ...
    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (2017-07-19)
    • Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study 

      Ahmadi-Abhari, Sara; Kaptoge, Stephen Kipkemoi; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BioMed Central, 2015-05-22)
      Background: Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large ...
    • Longitudinal associations between marine omega-3 supplement users and Coronary Heart Disease in a UK population-based cohort 

      Lentjes, Maria Antonetta; Keogh, RH; Welch, AA; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Journals, 2017-10-01)
      Objectives: Assess the association between marine omega-3 polyunsaturated fatty acid (n 3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. Design: Prospective cohort study, ...
    • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing 

      Easton, Douglas Frederick; Lesueur, Fabienne; Decker, Brennan; Michailidou, Kyriaki; Li, Jun; Allen, Jamie; Luccarini, Craig et al. (BMJ Group, 2016-02-26)
      Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and ...
    • Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures 

      Stone, Jennifer; Thompson, Deborah Jane; dos, Santos Silva Isabel; Scott, Christopher; Tamimi, Rulla M; Lindstrom, Sara; Kraft, Peter et al. (American Association for Cancer Research, 2015-04-10)
      Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 ...
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John Richard; Yuan, Xin; Scott, Robert; Henneman, Peter et al. (2012-01)
    • Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort 

      Keevil, Victoria Louise; Cooper, Andrew JM; Wijndaele, Katrien Lieve; Luben, Robert; Wareham, Nicholas John; Brage, Soren; Khaw, Kay-Tee (Wolters Kluwer, 2016-03-01)
      $\textbf{Purpose:}$ Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of ...
    • Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies 

      Wu, JHY; Marklund, M; Imamura, Fumiaki; et al,; Forouhi, Nita Gandhi; Luben, Robert; Khaw, Kay-Tee et al. (Elsevier, 2017-12-01)
      BACKGROUND: Metabolic effects of omega-6 polyunsaturated fatty acids (n-6 PUFA) remain contentious, and evidence is limited regarding their potential role in primary prevention of type 2 diabetes (T2D). METHODS: Global ...