Now showing items 43-62 of 72

    • Habitual chocolate consumption and the risk of incident heart failure among healthy men and women 

      Kwok, Chun Shing; Loke, Yoon K; Welch, Ailsa A; Luben, Robert; Lentjes, Maria Antonetta; Boekholdt, S Matthijs; Pfister, Roman et al. (Elsevier, 2016-01-28)
      Background: We aimed to examine the association between chocolate intake and the risk of incident heart failure in a UK general population. We conducted a systematic review and meta-analysis to quantify this association. ...
    • Ideal cardiovascular health and risk of cardiovascular events in the EPIC-Norfolk prospective population study 

      Lachman, Sangeeta; Peters, Ron JG; Lentjes, Maria Antonetta; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee et al. (SAGE, 2015-09-02)
      Background The American Heart Association (AHA) has prioritized seven cardiovascular health metrics to reduce the cardiovascular burden, including: body mass index, healthy diet, physical activity, smoking status, blood ...
    • Impact of physical activity on the risk of cardiovascular disease in middle-aged and older adults: EPIC Norfolk prospective population study. 

      Lachman, Sangeeta; Boekholdt, S Matthijs; Luben, Robert; Sharp, Stephen John; Brage, Soren; Khaw, Kay-Tee; Peters, Ron Jg et al. (SAGE, 2018-01)
      Abstract Background: There is broad consensus that regular physical activity yields major health benefits. However, current guidelines on physical activity are mainly aimed at middle-aged adults. It is unclear whether ...
    • Influence of Inflammatory Polyarthritis on Quantitative Heel Ultrasound Measurements 

      Pye, Stephen R; Marshall, Tarnya; Gaffney, Karl; Luben, Robert; Khaw, Kay-Tee; Silman, Alan J; Symmons, Deborah PM et al. (2012-07-26)
      AbstractBackgroundThere are few data concerning the impact of inflammatory polyarthritis (IP) on quantitative heel ultrasound (QUS) measurements. The aims of this analysis were i) to determine the influence of IP on QUS ...
    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (2017-07-19)
    • Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study 

      Ahmadi-Abhari, Sara; Kaptoge, Stephen Kipkemoi; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BioMed Central, 2015-05-22)
      Background: Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large ...
    • Longitudinal associations between marine omega-3 supplement users and Coronary Heart Disease in a UK population-based cohort 

      Lentjes, Maria Antonetta; Keogh, RH; Welch, AA; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Journals, 2017-10-01)
      Objectives: Assess the association between marine omega-3 polyunsaturated fatty acid (n 3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. Design: Prospective cohort study, ...
    • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing 

      Easton, Douglas Frederick; Lesueur, Fabienne; Decker, Brennan; Michailidou, Kyriaki; Li, Jun; Allen, Jamie; Luccarini, Craig et al. (BMJ Group, 2016-02-26)
      Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and ...
    • Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures 

      Stone, Jennifer; Thompson, Deborah Jane; dos, Santos Silva Isabel; Scott, Christopher; Tamimi, Rulla M; Lindstrom, Sara; Kraft, Peter et al. (American Association for Cancer Research, 2015-04-10)
      Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 ...
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John Richard; Yuan, Xin; Scott, Robert; Henneman, Peter et al. (2012-01)
    • Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort 

      Keevil, Victoria Louise; Cooper, Andrew JM; Wijndaele, Katrien Lieve; Luben, Robert; Wareham, Nicholas John; Brage, Soren; Khaw, Kay-Tee (Wolters Kluwer, 2016-03-01)
      $\textbf{Purpose:}$ Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of ...
    • Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies 

      Wu, JHY; Marklund, M; Imamura, Fumiaki; et al,; Forouhi, Nita Gandhi; Luben, Robert; Khaw, Kay-Tee et al. (Elsevier, 2017-12-01)
      BACKGROUND: Metabolic effects of omega-6 polyunsaturated fatty acids (n-6 PUFA) remain contentious, and evidence is limited regarding their potential role in primary prevention of type 2 diabetes (T2D). METHODS: Global ...
    • Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression 

      Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith et al. (Elsevier, 2015-06-11)
      Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association ...
    • Predicting admissions and time spent in hospital over a decade in a population-based record linkage study: the EPIC-Norfolk cohort 

      Luben, Robert; Hayat, Shabina Anwar; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Group, 2016-01-20)
      Objective To quantify hospital use in a general population over ten years follow up and to examine related factors in a general population based cohort. Design A prospective population based study of men and women. ...
    • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. 

      Ried, Janina S; Jeff M, Janina; Chu, Audrey Y; Bragg-Gresham, Jennifer L; van Dongen, Jenny; Huffman, Jennifer E; Ahluwalia, Tarunveer S et al. (2016-11-23)
    • RAD51B in Familial Breast Cancer 

      Pelttari, Liisa M; Khan, Sofia; Vuorela, Mikko; Kiiski, Johanna I; Vilske, Sara; Nevanlinna, Viivi; Ranta, Salla et al. (PLOS, 2016-05-05)
      Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study ...
    • Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. 

      Khaw, Kay-Tee; Sharp, Stephen John; Finikarides, Leila; Afzal, Islam; Lentjes, Maria Antonetta; Luben, Robert; Forouhi, Nita Gandhi (BMJ Journals, 2018-03-06)
      Abstract Introduction: High dietary saturated fat intake is associated with higher blood concentrations of LDL-cholesterol, an established risk factor for coronary heart disease. However, there is increasing interest ...
    • Rare, protein-truncating variants in $\textit{ATM}$, $\textit{CHEK2}$ and $\textit{PALB2}$, but not $\textit{XRCC2}$, are associated with increased breast cancer risks 

      Decker, B; Allen, J; Luccarini, C; Pooley, Karen Anne; Shah, Mitulkumar Nandlal; Bolla, MK; Wang, Qin et al.
      BACKGROUND: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To better characterise the ...
    • The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort 

      Bain, Lucy KM; Myint, Phyo K; Jennings, Amy; Lentjes, Maria Antonetta; Luben, Robert; Khaw, Kay-Tee; Wareham, Nicholas John et al. (Elsevier, 2015-05-31)
      Background: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary ...
    • Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study 

      Khawaja, Anthony P; Chan, Michelle PY; Yip, Jennifer LY; Broadway, David C; Garway-Heath, David F; Luben, Robert; Hayat, Shabina Anwar et al. (Association for Research in Vision and Ophthalmology, 2016-04)
      $\textbf{Purpose.}$ We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. $\textbf{Methods.}$ Participants of the European Prospective ...