Now showing items 47-66 of 72

    • Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. 

      Zillikens, M Carola; Demissie, Serkalem; Hsu, Yi-Hsiang; Yerges-Armstrong, Laura M; Chou, Wen-Chi; Stolk, Lisette; Livshits, Gregory et al. (2017-07-19)
    • Longitudinal association of C-reactive protein and Haemoglobin A1c over 13 years: the European Prospective Investigation into Cancer - Norfolk study 

      Ahmadi-Abhari, Sara; Kaptoge, Stephen Kipkemoi; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BioMed Central, 2015-05-22)
      Background: Type-2 diabetes is associated with systemic inflammation and higher C-reactive protein (CRP) levels. However, the longitudinal association of CRP and haemoglobin-A1c (HbA1c) has not been described in large ...
    • Longitudinal associations between marine omega-3 supplement users and Coronary Heart Disease in a UK population-based cohort 

      Lentjes, Maria Antonetta; Keogh, RH; Welch, AA; Mulligan, Angela Assumpta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Journals, 2017-10-01)
      Objectives: Assess the association between marine omega-3 polyunsaturated fatty acid (n 3 PUFA) intake from supplements, mainly cod liver oil, and coronary heart disease (CHD) mortality. Design: Prospective cohort study, ...
    • No evidence that protein truncating variants in BRIP1 are associated with breast cancer risk: implications for gene panel testing 

      Easton, Douglas Frederick; Lesueur, Fabienne; Decker, Brennan; Michailidou, Kyriaki; Li, Jun; Allen, Jamie; Luccarini, Craig et al. (BMJ Group, 2016-02-26)
      Background BRCA1 interacting protein C-terminal helicase 1 (BRIP1) is one of the Fanconi Anaemia Complementation (FANC) group family of DNA repair proteins. Biallelic mutations in BRIP1 are responsible for FANC group J, and ...
    • Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures 

      Stone, Jennifer; Thompson, Deborah Jane; dos, Santos Silva Isabel; Scott, Christopher; Tamimi, Rulla M; Lindstrom, Sara; Kraft, Peter et al. (American Association for Cancer Research, 2015-04-10)
      Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 ...
    • Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. 

      Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John Richard; Yuan, Xin; Scott, Robert; Henneman, Peter et al. (2012-01)
    • Objective Sedentary Time, Moderate-to-Vigorous Physical Activity, and Physical Capability in a British Cohort 

      Keevil, Victoria Louise; Cooper, Andrew JM; Wijndaele, Katrien Lieve; Luben, Robert; Wareham, Nicholas John; Brage, Soren; Khaw, Kay-Tee (Wolters Kluwer, 2016-03-01)
      $\textbf{Purpose:}$ Sedentariness has been proposed as an independent risk factor for poor health. However, few studies have considered associations of sedentary time (ST) with physical functional health independent of ...
    • Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies 

      Wu, JHY; Marklund, M; Imamura, Fumiaki; et al,; Forouhi, Nita Gandhi; Luben, Robert; Khaw, Kay-Tee et al. (Elsevier, 2017-12-01)
      BACKGROUND: Metabolic effects of omega-6 polyunsaturated fatty acids (n-6 PUFA) remain contentious, and evidence is limited regarding their potential role in primary prevention of type 2 diabetes (T2D). METHODS: Global ...
    • Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression 

      Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith et al. (Elsevier, 2015-06-11)
      Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association ...
    • Predicting admissions and time spent in hospital over a decade in a population-based record linkage study: the EPIC-Norfolk cohort 

      Luben, Robert; Hayat, Shabina Anwar; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Group, 2016-01-20)
      Objective To quantify hospital use in a general population over ten years follow up and to examine related factors in a general population based cohort. Design A prospective population based study of men and women. ...
    • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. 

      Ried, Janina S; Jeff M, Janina; Chu, Audrey Y; Bragg-Gresham, Jennifer L; van Dongen, Jenny; Huffman, Jennifer E; Ahluwalia, Tarunveer S et al. (2016-11-23)
    • RAD51B in Familial Breast Cancer 

      Pelttari, Liisa M; Khan, Sofia; Vuorela, Mikko; Kiiski, Johanna I; Vilske, Sara; Nevanlinna, Viivi; Ranta, Salla et al. (PLOS, 2016-05-05)
      Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study ...
    • Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. 

      Khaw, Kay-Tee; Sharp, Stephen John; Finikarides, Leila; Afzal, Islam; Lentjes, Maria Antonetta; Luben, Robert; Forouhi, Nita Gandhi (BMJ Journals, 2018-03-06)
      Abstract Introduction: High dietary saturated fat intake is associated with higher blood concentrations of LDL-cholesterol, an established risk factor for coronary heart disease. However, there is increasing interest ...
    • Rare, protein-truncating variants in $\textit{ATM}$, $\textit{CHEK2}$ and $\textit{PALB2}$, but not $\textit{XRCC2}$, are associated with increased breast cancer risks 

      Decker, B; Allen, J; Luccarini, C; Pooley, Karen Anne; Shah, Mitulkumar Nandlal; Bolla, MK; Wang, Qin et al.
      BACKGROUND: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To better characterise the ...
    • The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort 

      Bain, Lucy KM; Myint, Phyo K; Jennings, Amy; Lentjes, Maria Antonetta; Luben, Robert; Khaw, Kay-Tee; Wareham, Nicholas John et al. (Elsevier, 2015-05-31)
      Background: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary ...
    • Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study 

      Khawaja, Anthony P; Chan, Michelle PY; Yip, Jennifer LY; Broadway, David C; Garway-Heath, David F; Luben, Robert; Hayat, Shabina Anwar et al. (Association for Research in Vision and Ophthalmology, 2016-04)
      $\textbf{Purpose.}$ We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. $\textbf{Methods.}$ Participants of the European Prospective ...
    • Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort 

      Ishihara, Lianna S; Khaw, Kay-Tee; Luben, Robert; Bingham, Sheila; Welch, Ailsa; Day, Nicholas E; Brayne, Carol Elspeth (2005-08-24)
      Abstract Background Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential ...
    • Serum carbon and nitrogen stable isotopes as potential biomarkers of dietary intake and their relation with incident type 2 diabetes: the EPIC-Norfolk study 

      Patel, Pinal S; Cooper, Andrew John; O’Connell, Tamsin C; Kuhnle, Gunter GC; Kneale, Catherine K; Mulligan, Angela Assumpta; Luben, Robert et al. (American Society for Nutrition, 2014-07-02)
      Background - Stable-isotope ratios of carbon (13C/12C, expressed as δ13C) and nitrogen (15N/14N, or δ15N) have been proposed as potential nutritional biomarkers to distinguish between meat, fish, and plant-based foods. Objective ...
    • Sleep duration and risk of fatal and nonfatal stroke 

      Leng, Y; Cappuccio, FP; Wainwright, NWJ; Surtees, PG; Luben, Robert; Brayne, Carol Elspeth; Khaw, Kay-Tee (Lippincott Williams & Wilkins/Wolters Kluwer Health, 2015-02-25)
      $\textbf{Objective:}$ To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis. $\textbf{Methods:}$ The ...
    • Smoking and high-risk mammographic parenchymal patterns: a case-control study 

      Sala, Evis; Warren, Ruth ML; McCann, Jenny; Duffy, Stephen; Luben, Robert; Day, Nicholas E (1999-11-16)
      Statement of findings Current smoking was strongly and inversely associated with high-risk patterns, after adjustment for concomitant risk factors. Relative to never smokers, current smokers were significantly less likely ...