Now showing items 55-72 of 72

    • Polymorphisms in a Putative Enhancer at the 10q21.2 Breast Cancer Risk Locus Regulate NRBF2 Expression 

      Darabi, Hatef; McCue, Karen; Beesley, Jonathan; Michailidou, Kyriaki; Nord, Silje; Kar, Siddhartha; Humphreys, Keith et al. (Elsevier, 2015-06-11)
      Genome-wide association studies have identified SNPs near ZNF365 at 10q21.2 that are associated with both breast cancer risk and mammographic density. To identify the most likely causal SNPs, we fine mapped the association ...
    • Predicting admissions and time spent in hospital over a decade in a population-based record linkage study: the EPIC-Norfolk cohort 

      Luben, Robert; Hayat, Shabina Anwar; Wareham, Nicholas John; Khaw, Kay-Tee (BMJ Group, 2016-01-20)
      Objective To quantify hospital use in a general population over ten years follow up and to examine related factors in a general population based cohort. Design A prospective population based study of men and women. ...
    • A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape. 

      Ried, Janina S; Jeff M, Janina; Chu, Audrey Y; Bragg-Gresham, Jennifer L; van Dongen, Jenny; Huffman, Jennifer E; Ahluwalia, Tarunveer S et al. (2016-11-23)
    • RAD51B in Familial Breast Cancer 

      Pelttari, Liisa M; Khan, Sofia; Vuorela, Mikko; Kiiski, Johanna I; Vilske, Sara; Nevanlinna, Viivi; Ranta, Salla et al. (PLOS, 2016-05-05)
      Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study ...
    • Randomised trial of coconut oil, olive oil or butter on blood lipids and other cardiovascular risk factors in healthy men and women. 

      Khaw, Kay-Tee; Sharp, Stephen John; Finikarides, Leila; Afzal, Islam; Lentjes, Maria Antonetta; Luben, Robert; Forouhi, Nita Gandhi (BMJ Journals, 2018-03-06)
      Abstract Introduction: High dietary saturated fat intake is associated with higher blood concentrations of LDL-cholesterol, an established risk factor for coronary heart disease. However, there is increasing interest ...
    • Rare, protein-truncating variants in $\textit{ATM}$, $\textit{CHEK2}$ and $\textit{PALB2}$, but not $\textit{XRCC2}$, are associated with increased breast cancer risks 

      Decker, B; Allen, J; Luccarini, C; Pooley, Karen Anne; Shah, Mitulkumar Nandlal; Bolla, MK; Wang, Qin et al.
      BACKGROUND: Breast cancer (BC) is the most common malignancy in women and has a major heritable component. The risks associated with most rare susceptibility variants are not well estimated. To better characterise the ...
    • The relationship between dietary magnesium intake, stroke and its major risk factors, blood pressure and cholesterol, in the EPIC-Norfolk cohort 

      Bain, Lucy KM; Myint, Phyo K; Jennings, Amy; Lentjes, Maria Antonetta; Luben, Robert; Khaw, Kay-Tee; Wareham, Nicholas John et al. (Elsevier, 2015-05-31)
      Background: Dietary magnesium could modify the major stroke risk factors, high blood pressure (BP) and cholesterol, but has been understudied in both sexes in a single population. This study aimed to investigate if dietary ...
    • Retinal Nerve Fiber Layer Measures and Cognitive Function in the EPIC-Norfolk Cohort Study 

      Khawaja, Anthony P; Chan, Michelle PY; Yip, Jennifer LY; Broadway, David C; Garway-Heath, David F; Luben, Robert; Hayat, Shabina Anwar et al. (Association for Research in Vision and Ophthalmology, 2016-04)
      $\textbf{Purpose.}$ We examined the relationship between retinal nerve fiber layer (RNFL) thickness and cognitive function in a population of older British adults. $\textbf{Methods.}$ Participants of the European Prospective ...
    • Self-reported parkinsonian symptoms in the EPIC-Norfolk cohort 

      Ishihara, Lianna S; Khaw, Kay-Tee; Luben, Robert; Bingham, Sheila; Welch, Ailsa; Day, Nicholas E; Brayne, Carol Elspeth (2005-08-24)
      Abstract Background Parkinsonian symptoms have been associated with increased morbidity and mortality. Several studies have reported on the prevalence of signs and symptoms. Symptoms questionnaires can identify potential ...
    • Serum carbon and nitrogen stable isotopes as potential biomarkers of dietary intake and their relation with incident type 2 diabetes: the EPIC-Norfolk study 

      Patel, Pinal S; Cooper, Andrew John; O’Connell, Tamsin C; Kuhnle, Gunter GC; Kneale, Catherine K; Mulligan, Angela Assumpta; Luben, Robert et al. (American Society for Nutrition, 2014-07-02)
      Background - Stable-isotope ratios of carbon (13C/12C, expressed as δ13C) and nitrogen (15N/14N, or δ15N) have been proposed as potential nutritional biomarkers to distinguish between meat, fish, and plant-based foods. Objective ...
    • Sleep duration and risk of fatal and nonfatal stroke 

      Leng, Y; Cappuccio, FP; Wainwright, NWJ; Surtees, PG; Luben, Robert; Brayne, Carol Elspeth; Khaw, Kay-Tee (Lippincott Williams & Wilkins/Wolters Kluwer Health, 2015-02-25)
      $\textbf{Objective:}$ To study the association between sleep duration and stroke incidence in a British population and to synthesize our findings with published results through a meta-analysis. $\textbf{Methods:}$ The ...
    • Smoking and high-risk mammographic parenchymal patterns: a case-control study 

      Sala, Evis; Warren, Ruth ML; McCann, Jenny; Duffy, Stephen; Luben, Robert; Day, Nicholas E (1999-11-16)
      Statement of findings Current smoking was strongly and inversely associated with high-risk patterns, after adjustment for concomitant risk factors. Relative to never smokers, current smokers were significantly less likely ...
    • Sulfate, Nitrate and Blood Pressure - An EPIC Interaction between Sulfur and Nitrogen 

      Kuhnle, GG; Luben, Robert; Khaw, Kay-Tee; Feelisch, M
      Nitrate (NO3−)-rich foods such as green leafy vegetables are not only part of a healthy diet, but increasingly marketed for primary prevention of cardiovascular disease (CVD) and used as ergogenic aids by competitive ...
    • Television Viewing, Walking Speed and Grip Strength in a Prospective Cohort Study 

      Keevil, Victoria Louise; Wijndaele, Katrien Lieve; Luben, Robert; Sayer, Avan A; Wareham, Nicholas John; Khaw, Kay-Tee (2014-07-18)
      Purpose Television (TV) watching is the most prevalent sedentary leisure-time activity in the United Kingdom. We examined associations between TV viewing time, measured over 10 years, and two objective measures of ...
    • Topical Beta-blockers and Cardiovascular Mortality: Systematic review and meta-analysis with data from the EPIC-Norfolk cohort study 

      Pinnock, Claude; Yip, Jennifer LY; Khawaja, Anthony P; Luben, Robert; Hayat, Shabina Anwar; Broadway, David C; Foster, Paul J et al. (Taylor & Francis, 2016-08-23)
      ${\bf Purpose:}$ To determine if topical beta-blocker use is associated with increased cardiovascular mortality, particularly amongst people with self reported glaucoma. ${\bf Methods:}$ All participants who participated ...
    • Weather, day length and physical activity in older adults: Cross-sectional results from the European Prospective Investigation into Cancer and Nutrition (EPIC) Norfolk Cohort 

      Wu, Y-T; Luben, Robert; Wareham, Nicholas John; Griffin, Simon James; Jones, Andy (Public Library of Science (PLoS), 2017-05-31)
      $\textbf{Background}$ A wide range of environmental factors have been related to active ageing, but few studies have explored the impact of weather and day length on physical activity in older adults. We investigate the ...
    • Weight change and 15 year mortality: results from the European Prospective Investigation into Cancer in Norfolk (EPIC-Norfolk) cohort study. 

      Mulligan, Angela Assumpta; Lentjes, Maria Antonetta; Luben, Robert; Wareham, Nicholas John; Khaw, Kay-Tee (Springer Nature, 2018-01)
      Studies have reported a higher mortality risk associated with weight loss, particularly in middle-aged and older adults, although some of these studies did find that gaining weight was also associated with an increased ...
    • ω-3 Polyunsaturated Fatty Acid Biomarkers and Coronary Heart Disease 

      Del, Gobbo Liana C; Imamura, Fumiaki; Aslibekyan, Stella; Marklund, Matti; Virtanen, Jyrki K; Wennberg, Maria; Yakoob, Mohammad Y et al. (American Medical Association, 2016-06-27)
      Importance The role of ω-3 polyunsaturated fatty acids for primary prevention of coronary heart disease (CHD) remains controversial. Most prior longitudinal studies evaluated self-reported consumption rather than ...