Now showing items 1-10 of 10

    • Common ERBB2polymorphisms and risk of breast cancer in a white British population: a case-control study 

      Benusiglio, Patrick R.; Lesueur, Fabienne; Luccarini, Craig; Conroy, Donald M.; Shah, Mitul; Easton, Douglas F.; Day, Nick E. et al. (2005-01-12)
      Abstract Introduction About two-thirds of the excess familial risk associated with breast cancer is still unaccounted for and may be explained by multiple weakly predisposing alleles. A gene thought to be involved in ...
    • Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs 

      Benusiglio, Patrick R.; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison M. et al. (2005-07-19)
      Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast ...
    • CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen 

      Abraham, Jean E.; Maranian, Mel J.; Driver, Kristy E.; Platte, Radka; Kalmyrzaev, Bolot; Baynes, Caroline; Luccarini, Craig et al. (2010-08-23)
      Abstract Introduction Tamoxifen is one of the most effective adjuvant breast cancer therapies available. Its metabolism involves the phase I enzyme, cytochrome P4502D6 (CYP2D6), encoded by the highly polymorphic CYP2D6 ...
    • Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation 

      Ghoussaini, Maya; Edwards, Stacey L.; Michailidou, Kyriaki; Nord, Silje; Cowper-Sal•lari, Richard; Desai, Kinjal; Kar, Siddhartha et al. (NPG, 2014-09-23)
      GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine-mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the “iCOGS” genotyping ...
    • Fine scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1 

      Glubb, Dylan M.; Maranian, Mel J.; Michailidou, Kyriaki; Pooley, Karen A.; Meyer, Kerstin B.; Kar, Siddhartha; Carlebur, Saskia et al. (Cell/Elsevier, 18/12/2014)
      Genome Wide Association Studies (GWAS) revealed SNP rs889312 on 5q11.2 to be associated with breast cancer risk in women of European ancestry. In an attempt to identify the biologically relevant variants, we analysed 909 ...
    • Fine scale mapping of the 5q11.2 breast cancer locus reveals at least three independent risk variants regulating MAP3K1. 

      Glubb, Dylan M.; Maranian, Mel J.; Michailidou, Kyriaki; Pooley, Karen A.; Meyer, Kerstin B.; Kar, Siddhartha; Carlebur, Saskia et al. (2015-12-18)
    • Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer. 

      Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe; Lush, Michael J.; Maranian, Mel J. et al. (NPG, 2015-03-09)
      Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new ...
    • Identification and characterisation of novel associations in the CASP8/ALS2CR12 region on chromosome 2 with breast cancer risk 

      Lin, Wei-Yu; Camp, Nicola J.; Ghoussaini, Maya; Beesley, Jonathan; Michailidou, Kyriaki; Hopper, John L.; Apicella, Carmel et al. (Oxford University Press, 2014-08-28)
      Previous studies have suggested that polymorphisms in CASP8 on chromosome 2 are associated with breast cancer risk. To clarify the role of CASP8 in breast cancer susceptibility we carried out dense genotyping of this region ...
    • Saliva samples are a viable alternative to blood samples as a source of DNA for high throughput genotyping 

      Abraham, Jean E.; Maranian, Mel J.; Spiteri, Inmaculada; Russell, Roslin; Ingle, Susan; Luccarini, Craig; Earl, Helena M. et al. (2012-05-30)
      Abstract Background The increasing trend for incorporation of biological sample collection within clinical trials requires sample collection procedures which are convenient and acceptable for both patients and clinicians. ...
    • Seq4SNPs: new software for retrieval of multiple, accurately annotated DNA sequences ready formatted for SNP assay design. 

      Field, Helen I.; Scollen, Serena A.; Luccarini, Craig; Baynes, Caroline; Morrison, Jonathan; Dunning, Alison M.; Easton, Douglas F. et al. (2009-06-12)
      Abstract Background In moderate-throughput SNP genotyping there was a gap in the workflow, between choosing a set of SNPs and submitting their sequences to proprietary assay design software, which was not met by existing ...