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    • Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. 

      Asim, Mohammad; Tarish, Firas; Zecchini, Heather I; Sanjiv, Kumar; Gelali, Eleni; Massie, Charles E; Baridi, Ajoeb et al. (Nature Publishing Group, 2017-08-29)
      Emerging data demonstrate homologous recombination (HR) defects in castration resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here, we demonstrate a direct requirement for the androgen ...