Now showing items 1-5 of 5

• #### Evaluation of Polygenic Risk Scores for Breast and Ovarian Cancer Risk Prediction in BRCA1 and BRCA2 Mutation Carriers ﻿

(Oxford University Press, 2017-03-09)
$\textbf{Background:}$ Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several ...
• #### Familial relative risks for breast cancer by pathological subtype: a population-based cohort study ﻿

(2010-02-10)
Abstract Introduction The risk of breast cancer to first degree relatives of breast cancer patients is approximately twice that of the general population. Breast cancer, however, is a heterogeneous disease and it is plausible ...
• #### Incorporating tumour pathology information into breast cancer risk prediction algorithms ﻿

(2010-05-18)
Abstract Introduction Mutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian cancer. The risk prediction algorithm BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation ...
• #### Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium. ﻿

(Oxford University Press, 2018-04)
Background: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRSs and environmental risk factors will improve risk ...