Now showing items 3-5 of 5

    • Incorporating tumour pathology information into breast cancer risk prediction algorithms 

      Mavaddat, Nasim; Rebbeck, Timothy R; Lakhani, Sunil R; Easton, Douglas Frederick; Antoniou, Antonis (2010-05-18)
      Abstract Introduction Mutations in BRCA1 and BRCA2 confer high risks of breast cancer and ovarian cancer. The risk prediction algorithm BOADICEA (Breast and Ovarian Analysis of Disease Incidence and Carrier Estimation ...
    • Joint associations of a polygenic risk score and environmental risk factors for breast cancer in the Breast Cancer Association Consortium. 

      Rudolph, Anja; Song, Minsun; Brook, Mark N; Milne, Roger L; Mavaddat, Nasim; Michailidou, Kyriaki; Bolla, Manjeet K et al. (Oxford University Press, 2018-01-05)
      Background: Polygenic risk scores (PRS) for breast cancer can be used to stratify the population into groups at substantially different levels of risk. Combining PRSs and environmental risk factors will improve risk ...
    • Polygenic risk score is associated with increased disease risk in 52 Finnish breast cancer families 

      Muranen, TA; Mavaddat, Nasim; Khan, S; Fagerholm, R; Pelttari, L; Lee, Andrew John; Aittomäki, K et al. (Kluwer Academic Publishers, 2016-08)
      The risk of developing breast cancer is increased in women with family history of breast cancer and particularly in families with multiple cases of breast or ovarian cancer. Nevertheless, many women with a positive family ...