Now showing items 2-7 of 7

    • Development of assessment toolkits for improving the diagnosis of the Lewy body dementias: feasibility study within the DIAMOND Lewy study. 

      Thomas, Alan J; Taylor, John Paul; McKeith, Ian; Bamford, Claire; Burn, David; Allan, Louise; O'Brien, John Tiernan (Wiley, 2016-12-08)
      $\textbf{Objective:}$ The Lewy body dementias (LBD, dementia with Lewy bodies and Parkinson's disease dementia) are the second most common cause of neurodegenerative dementia but remain under-recognised, with long delays ...
    • DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT 

      Jones, Rob; Sheehan, Bart; Phillips, Patrick; Juszczak, Ed; Adams, Jessica; Baldwin, Ashley; Ballard, Clive et al. (2009-07-24)
      Abstract Background Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while ...
    • Grey matter atrophy in prodromal stage of dementia with Lewy bodies and Alzheimer's disease 

      Blanc, Frederic; Colloby, Sean J; Cretin, Benjamin; de, Sousa Paulo Loureiro; Demuynck, Catherine; O'Brien, John Tiernan; Martin-Hunyadi, Catherine et al. (BioMed Central, 2016)
      ${\bf Introduction:}$ Little is known about the patterns of brain atrophy inprodromal Dementia with Lewy bodies (pro-DLB). ${\bf Methods:}$ In this study, we used SPM8-DARTEL to measure gray matter (GM) volume and ...
    • Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study 

      Byford, M; Brayne, Carol Elspeth; McKeith, Ian; Chatfield, Mark; Ince, Paul G; Matthews, Fiona E; MRC-CFAS, (2009-06-15)
      Abstract Background Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in ...
    • Non-pharmacological interventions for Lewy body dementia: a systematic review. 

      Connors, Michael H; Quinto, Lena; McKeith, Ian; Brodaty, Henry; Allan, Louise; Bamford, Claire; Thomas, Alan et al. (Cambridge University Press, 2017-11-16)
      Lewy body dementia (consisting of dementia with Lewy bodies and Parkinson’s disease dementia) is a common neurodegenerative disease characterised by visual hallucinations, fluctuating attention, motor disturbances, falls, ...
    • Pharmacological Management of Lewy Body Dementia: A Systematic Review and Meta-Analysis 

      Stinton, Chris; McKeith, Ian; Taylor, John-Paul; Lafortune, Louise; Mioshi, Eneida; Mak, Elijah; Cambridge, Victoria et al. (American Psychiatric Association, 2015-06-18)
      Objective: The authors examined research on effects, costs, and patient and caregiver views of pharmacological management strategies for Lewy body dementia. Method: Studies were identified through bibliographic databases, ...