Now showing items 2-4 of 4

    • DLK1/PREF1 regulates nutrient metabolism and protects from steatosis 

      Charalambous, Marika; Teixeira, Da Rocha Simao; Radford, Elizabeth Jane; Medina-Gomez, Gema; Curran, Scott; Pinnock, Scarlett B; Ferrón, Sacri R et al. (PNAS, 2014-10-27)
      Nonalcoholic fatty liver disease (NAFLD) is associated with insulin resistance and obesity, as well as progressive liver dysfunction. Recent animal studies have underscored the importance of hepatic growth hormone (GH) ...
    • Early Peroxisome proliferator-activated receptor gamma regulated genes involved in expansion of pancreatic beta cell mass 

      Vivas, Yurena; Martinez-Garcia, Cristina; Izquierdo, Adriana; Garcia-Garcia, Francisco; Callejas, Sergio; Velasco, Ismael; Campbell, Mark et al. (2011-12-30)
      Abstract Background The progression towards type 2 diabetes depends on the allostatic response of pancreatic beta cells to synthesise and secrete enough insulin to compensate for insulin resistance. The endocrine pancreas ...
    • Increased Dihydroceramide/ceramide ratio mediated by defective expression of degs1 impairs adipocyte differentiation and function 

      Barbarroja, Nuria; Rodriguez-Cuenca, Sergio; Nygren, Heli; Camargo, Antonio; Pirraco, Ana; Relat, Joana; Cuadrado, Irene et al. (American Diabetes Association, 2014-10-28)
      Adipose tissue dysfunction is an important determinant of obesity-associated lipid induced metabolic complications. Ceramides are well known mediators of lipid induced insulin resistance in peripheral organs such as muscle. ...