Now showing items 1-7 of 7

    • esyN: Network Building, Sharing and Publishing 

      Bean, Daniel M.; Heimbach, Joshua; Ficorella, Lorenzo; Micklem, Gos; Oliver, Stephen G.; Favrin, Giorgio (PLOS, 2014-09-02)
      The construction and analysis of networks is increasingly widespread in biological research. We have developed esyN (“easy networks”) as a free and open source tool to facilitate the exchange of biological network ...
    • Expression of multiple horizontally acquired genes is a hallmark of both vertebrate and invertebrate genomes 

      Crisp, Alastair; Boschetti, Chiara; Perry, Malcolm; Tunnacliffe, Alan; Micklem, Gos (BioMed Central, 2015-03-13)
      Background: A fundamental concept in biology is that heritable material, DNA, is passed from parent to offspring, a process called vertical gene transfer. An alternative mechanism of gene acquisition is through horizontal ...
    • FlyMine: an integrated database for Drosophila and Anopheles genomics 

      Lyne, Rachel; Smith, Richard; Rutherford, Kim; Wakeling, Matthew; Varley, Andrew; Guillier, Francois; Janssens, Hilde et al. (2007-07-05)
      Abstract FlyMine is a data warehouse that addresses one of the important challenges of modern biology: how to integrate and make use of the diversity and volume of current biological data. Its main focus is genomic and ...
    • Identification and analysis of serpin-family genes by homology and synteny across the 12 sequenced Drosophilid genomes 

      Garrett, Matthew; Fullaondo, Ane; Troxler, Laurent; Micklem, Gos; Gubb, David (2009-10-22)
      Abstract Background The Drosophila melanogaster genome contains 29 serpin genes, 12 as single transcripts and 17 within 6 gene clusters. Many of these serpins have a conserved "hinge" motif characteristic of active proteinase ...
    • Multiple functionally divergent and conserved copies of alpha tubulin in bdelloid rotifers 

      Eyres, Isobel; Frangedakis, Eftychios; Fontaneto, Diego; Herniou, Elisabeth A.; Boschetti, Chiara; Carr, Adrian; Micklem, Gos et al. (2012-08-17)
      AbstractBackgroundBdelloid rotifers are microscopic animals that have apparently survived without sex for millions of years and are able to survive desiccation at all life stages through a process called anhydrobiosis. ...
    • The 3rd DBCLS BioHackathon: improving life science data integration with Semantic Web technologies 

      Katayama, Toshiaki; Wilkinson, Mark D.; Micklem, Gos; Kawashima, Shuichi; Yamaguchi, Atsuko; Nakao, Mitsuteru; Yamamoto, Yasunori et al. (2013-02-11)
      Abstract Background BioHackathon 2010 was the third in a series of meetings hosted by the Database Center for Life Sciences (DBCLS) in Tokyo, Japan. The overall goal of the BioHackathon series is to improve the quality and ...
    • The impact of quantitative optimization of hybridization conditions on gene expression analysis 

      Sykacek, Peter; Kreil, David P.; Meadows, Lisa A.; Auburn, Richard P.; Fischer, Bettina; Russell, Steven R.; Micklem, Gos (2011-03-14)
      Abstract Background With the growing availability of entire genome sequences, an increasing number of scientists can exploit oligonucleotide microarrays for genome-scale expression studies. While probe-design is a major ...