Now showing items 1-9 of 9

    • Choline kinase alpha as an Androgen Receptor Chaperone and Prostate Cancer Therapeutic Target 

      Asim, Mohammad; Massie, Charles Edward; Orafidiya, Folake; Pértega-Gomes, Nelma; Warren, Anne Y; Esmaeili, Mohsen; Selth, Luke A et al. (Oxford University Press, 2015)
    • Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) 

      Klionsky, Daniel J; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki et al. (Taylor & Francis, 2016-01-21)
    • Identification of shared genetic variants between schizophrenia and lung cancer. 

      Zuber, Verena; Jönsson, Erik G; Frei, Oleksandr; Witoelar, Aree; Thompson, Wesley K; Schork, Andrew J; Bettella, Francesco et al. (Nature Publishing Group, 2018-01-12)
      Epidemiology studies suggest associations between schizophrenia and cancer. However, the underlying genetic mechanisms are not well understood, and difficult to identify from epidemiological data. We investigated if there ...
    • The Importance of DNA methylation in Prostate Cancer development 

      Massie, Charles Edward; Mills, Ian G; Lynch, Andrew Graeme (Elsevier, 2016-04-24)
      After briefly reviewing the nature of DNA methylation, its general role in cancer and the tools available to interrogate it, we consider the literature surrounding DNA methylation as relating to prostate cancer. Specific ...
    • A new look towards BAC-based array CGH through a comprehensive comparison with oligo-based array CGH 

      Wicker, Nicolas; Carles, Annaick; Mills, Ian G; Wolf, Maija; Veerakumarasivam, Abhi; Edgren, Henrik; Boileau, Fabrice et al. (2007-03-29)
      Abstract Background Currently, two main technologies are used for screening of DNA copy number; the BAC (Bacterial Artificial Chromosome) and the recently developed oligonucleotide-based CGH (Chromosomal Comparative Genomic ...
    • Nuclear ARRB1 induces pseudohypoxia and cellular metabolism reprogramming in prostate cancer. 

      Zecchini, Vincent; Madhu, Madhu; Russell, Roslin; Pértega-Gomes, Nelma; Warren, Anne; Gaude, Edoardo; Borlido, Joana et al. (2014-06)
    • Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. 

      Seibert, Tyler M; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Parsons, J Kellogg; Eeles, Rosalind A et al. (BMJ, 2018-01-10)
      Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines ...
    • Pro-neural transcription factors as cancer markers 

      Vias, Maria; Massie, Charles Edward; East, Philip; Scott, Helen; Warren, Anne; Zhou, Zongxiang; Nikitin, Alexander Yu et al. (2008-05-19)
      Abstract Background The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine ...
    • Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. 

      Asim, Mohammad; Tarish, Firas; Zecchini, Heather I; Sanjiv, Kumar; Gelali, Eleni; Massie, Charles Edward; Baridi, Ajoeb et al. (Nature Publishing Group, 2017-08-29)
      Emerging data demonstrate homologous recombination (HR) defects in castration resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here, we demonstrate a direct requirement for the androgen ...