Now showing items 2-3 of 3

    • Pro-neural transcription factors as cancer markers 

      Vias, Maria; Massie, Charles E; East, Philip; Scott, Helen; Warren, Anne; Zhou, Zongxiang; Nikitin, Alexander Yu et al. (2008-05-19)
      Abstract Background The aberrant transcription in cancer of genes normally associated with embryonic tissue differentiation at various organ sites may be a hallmark of tumour progression. For example, neuroendocrine ...
    • Synthetic lethality between androgen receptor signalling and the PARP pathway in prostate cancer. 

      Asim, Mohammad; Tarish, Firas; Zecchini, Heather I; Sanjiv, Kumar; Gelali, Eleni; Massie, Charles E; Baridi, Ajoeb et al. (Nature Publishing Group, 2017-08-29)
      Emerging data demonstrate homologous recombination (HR) defects in castration resistant prostate cancers, rendering these tumours sensitive to PARP inhibition. Here, we demonstrate a direct requirement for the androgen ...