Now showing items 1-3 of 3

    • Chromosomal instability determines taxane sensitivity - supplementary materials 

      Swanton, Charles; Nicke, Barbara; Schuett, Marion; Eklund, Aron C.; Ng, Charlotte; Li, Qiyuan; Hardcastle, Thomas et al. (2009-04-24)
      Microtubule-stabilizing (MTS) agents, such as taxanes, are important chemotherapeutics with a poorly understood mechanism of action. We identified a set of genes repressed in multiple cell lines in response to MTS agents ...
    • Spatial and temporal heterogeneity in high-grade serous ovarian cancer: a phylogenetic reconstruction 

      Schwarz, Roland F; Ng, Charlotte; Cooke, Susanna L; Newmann, Scott; Temple, Jillian; Piskorz, Anna; Gale, Davina Gillian et al. (PLOS, 2015-02-24)
      Background The major clinical challenge in the treatment of high-grade serous ovarian cancer (HGSOC) is the development of progressive resistance to platinum-based chemotherapy. The objective of this study was to determine ...
    • Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes 

      Schulte, Ina; Batty, Elizabeth M; Pole, Jessica CM; Blood, Katherine A; Mo, Steven; Cooke, Susanna L; Ng, Charlotte et al. (2012-12-22)
      Abstract Background It has recently emerged that common epithelial cancers such as breast cancers have fusion genes like those in leukaemias. In a representative breast cancer cell line, ZR-75-30, we searched for fusion ...