Now showing items 4-8 of 8

    • Paediatric extracranial germ-cell tumours 

      Shaikh, Furqan; Murray, Matthew Jonathan; Amatruda, James F; Coleman, Nicholas; Nicholson, James C; Hale, Juliet P; Pashankar, Farzana et al. (Elsevier, 2016-03-29)
      Management of paediatric extracranial germ-cell tumours carries a unique set of challenges. Germ-cell tumours are a heterogeneous group of neoplasms that present across a wide age range and vary in site, histology, and ...
    • A pipeline to quantify serum and cerebrospinal fluid microRNAs for diagnosis and detection of relapse in paediatric malignant germ cell tumours 

      Murray, Matthew Jonathan; Bell, Emma; Raby, Katie L; Rijlaarsdam, Martin A; Gillis, Ad JM; Looijenga, Leendert HJ; Brown, Helen et al. (NPG, 2015-12-18)
      BACKGROUND: The current biomarkers alpha fetoprotein and human chorionic gonadotropin have limited sensitivity and specificity for diagnosing malignant germ cell tumours (GCTs). MicroRNAs (miRNAs) from the miR-371~373 and ...
    • Revised Risk Classification for Pediatric Extracranial Germ Cell Tumors Based on 25 Years of Clinical Trial Data from the United Kingdom and United States 

      Frazier, A Lindsay; Hale, Juliet P; Rodriguez-Galindo, Carlos; Dang, Ha; Olson, Thomas; Murray, Matthew Jonathan; Amatruda, James F et al. (American Society of Clinical Oncology, 2014-12-01)
      Purpose Risk stratification of malignant extracranial pediatric germ cell tumors (GCT). Patients and methods Data from seven GCT trials conducted by the Children’s Oncology Group (United States) or the Children’s Cancer ...
    • Solid tumors of childhood display specific serum microRNA profiles 

      Murray, Matthew Jonathan; Raby, Katie L; Saini, Harpreet K; Bailey, Shivani; Wool, Sophie V; Tunnacliffe, Jane M; Enright, Anton James et al. (American Association for Cancer Research, 2014-11-21)
      Background: Serum biomarkers for diagnosis and risk-stratification of childhood solid tumors would improve the accuracy and timeliness of diagnosis and reduce the need for invasive biopsies. We hypothesized that differential ...
    • The two most common histological subtypes of malignant germ cell tumour are distinguished by global microRNA profiles, associated with differential transcription factor expression 

      Murray, Matthew Jonathan; Saini, Harpreet K; van, Dongen Stijn; Palmer, Roger D; Muralidhar, Balaji; Pett, Mark R; Piipari, Matias et al. (2010-11-08)
      Abstract Background We hypothesised that differences in microRNA expression profiles contribute to the contrasting natural history and clinical outcome of the two most common types of malignant germ cell tumour (GCT), yolk ...