Now showing items 1-5 of 5

    • Haploinsufficiency and the sex chromosomes from yeasts to humans 

      de Clare, Michaela; Pir, Pinar; Oliver, Stephen G (2011-02-28)
      Abstract Background Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness. Haploinsufficiency is increasingly implicated in human ...
    • How yeast re-programmes its transcriptional profile in response to different nutrient impulses 

      Dikicioglu, Duygu; Karabekmez, Erkan; Rash, Bharat; Pir, Pinar; Kirdar, Betul; Oliver, Stephen G (2011-09-25)
      Abstract Background A microorganism is able to adapt to changes in its physicochemical or nutritional environment and this is crucial for its survival. The yeast, Saccharomyces cerevisiae, has developed mechanisms to respond ...
    • Information management for high content live cell imaging 

      Jameson, Daniel; Turner, David A; Ankers, John; Kennedy, Stephnie; Ryan, Sheila; Swainston, Neil; Griffiths, Tony et al. (2009-07-21)
      Abstract Background High content live cell imaging experiments are able to track the cellular localisation of labelled proteins in multiple live cells over a time course. Experiments using high content live cell imaging ...
    • Model organism databases: essential resources that need the support of both funders and users 

      Oliver, Stephen G; Lock, Antonia; Harris, Midori A; Nurse, Paul; Wood, Valerie (2016-06-22)
      Abstract Modern biomedical research depends critically on access to databases that house and disseminate genetic, genomic, molecular, and cell biological knowledge. Even as the explosion of available genome ...
    • The genetic control of growth rate: a systems biology study in yeast. 

      Pir, Pinar; Gutteridge, Alex; Wu, Jian; Rash, Bharat; Kell, Douglas B; Zhang, Nianshu; Oliver, Stephen G (2012-01-13)
      Abstract Background Control of growth rate is mediated by tight regulation mechanisms in all free-living organisms since long-term survival depends on adaptation to diverse environmental conditions. The yeast, Saccharomyces ...