Now showing items 1-9 of 9

    • Adiposity, hormone replacement therapy use and breast cancer risk by age and hormone receptor status: a large prospective cohort study 

      Ritte, Rebecca; Lukanova, Annekatrin; Berrino, Franco; Dossus, Laure; Tjønneland, Anne; Olsen, Anja; Overvad, Thure F. et al. (2012-05-14)
      Abstract Introduction Associations of hormone-receptor positive breast cancer with excess adiposity are reasonably well characterized; however, uncertainty remains regarding the association of body mass index (BMI) with ...
    • The association of coffee intake with liver cancer risk is mediated by biomarkers of inflammation and hepatocellular injury: data from the European Prospective Investigation into Cancer and Nutrition 

      Aleksandrova, Krasimira; Bamia, Christina; Drogan, Dagmar; Lagiou, Pagona; Trichopoulou, Antonia; Jenab, Mazda; Fedirko, Veronika et al. (American Society for Nutrition, 2015-11-11)
      BACKGROUND: Higher coffee intake has been purportedly related to a lower risk of liver cancer. However, it remains unclear whether this association may be accounted for by specific biological mechanisms. ...
    • Association of plasma phospholipid omega-3 and omega-6 polyunsaturated fatty acids with type 2 diabetes: The EPIC-InterAct case-cohort study 

      Forouhi, Nita G.; Imamura, Fumiaki; Sharp, Stephen J.; Koulman, Albert; Schulze, Matthias B.; Zheng, Jusheng; Ye, Zheng et al. (Public Library of Science, 2016)
      ${\bf Background:}$ Whether and how n-3 and n-6 polyunsaturated fatty acids (PUFAs) are related to type 2 diabetes (T2D) is debated. Objectively measured plasma PUFAs can help to clarify these associations. ${\bf ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert A.; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen J.; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y.; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study 

      Vineis, Paolo; Hoek, Gerard; Krzyzanowski, Michal; Vigna-Taglianti, Federica; Veglia, Fabrizio; Airoldi, Luisa; Overvad, Kim et al. (2007-02-15)
      Abstract Background Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of ...
    • Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition 

      Rohrmann, Sabine; Overvad, Kim; Bueno-de-Mesquita, H. B.; Jakobsen, Marianne U.; Egeberg, Rikke; Tjønneland, Anne; Nailler, Laura et al. (2013-03-07)
      Abstract Background Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study ...
    • Physical Activity and all-cause mortality across levels of general and abdominal adiposity: The European Prospective Investigation into Cancer and Nutrition Study (EPIC) 

      Ekelund, Ulf; Ward, Heather A.; Norat, Teresa; Luan, Jian'an; May, Anne M.; Weiderpass, Elisabete; Sharp, Stephen S. et al. (American Society for Nutrition, 2015-01-14)
      Background: The higher risk of death resulting from excess adiposity may be attenuated by physical activity (PA). However, the theoretical number of deaths reduced by eliminating physical inactivity compared with overall ...
    • The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk 

      Campa, Daniele; Husing, Anika; McKay, James D.; Sinilnikova, Olga M.; Vogel, Ulla; Tjonneland, Anne; Overvad, Kim et al. (2010-10-18)
      Abstract Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass ...