Now showing items 2-6 of 6

    • Blood lipids and prostate cancer: a Mendelian randomization analysis 

      Bull, Caroline J.; Bonilla, Carolina; Holly, Jeff M. P.; Perks, Claire M.; Davies, Neil; Haycock, Philip; Yu, Oriana Hoi Yun et al. (Wiley, 2016-03-19)
      Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS 

      Southey, Melissa C.; Goldgar, David; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William et al. (BMJ Publishing Group, 2016)
      Background: The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
    • Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort 

      Bonilla, Carolina; Lewis, Sarah J.; Martin, Richard M.; Donovan, Jenny L.; Hamdy, Freddie C.; Neal, David E.; Eeles, Rosalind et al. (BioMed Central, 2016-04-04)
      Background: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates ...
    • Sequence similarity between stereocilin and otoancorin points to a unified mechanism for mechanotransduction in the mammalian inner ear 

      Jovine, Luca; Park, Jong; Wassarman, Paul M. (2002-11-25)
      Abstract Background Interaction between hair cells and acellular gels of the mammalian inner ear, the tectorial and otoconial membranes, is crucial for mechanoreception. Recently, otoancorin was suggested to be a mediator ...
    • Visualisation and graph-theoretic analysis of a large-scale protein structural interactome 

      Bolser, Dan M.; Dafas, Panos; Harrington, Richard; Park, Jong; Schroeder, Michael (2003-10-08)
      Abstract Background Large-scale protein interaction maps provide a new, global perspective with which to analyse protein function. PSIMAP, the Protein Structural Interactome Map, is a database of all the structurally ...