Now showing items 13-19 of 19

    • A novel hybrid SCCmec-mecC region in Staphylococcus sciuri 

      Harrison, Ewan M.; Paterson, Gavin K.; Holden, Matthew T. G.; Ba, Xiaoliang; Rolo, Joana; Morgan, Fiona J. E.; Pichon, Bruno et al. (Oxford University Press, 2013-12-02)
      Objectives: Methicillin resistance in Staphylococcus spp. results from the expression of an alternative penicillin-binding protein 2a (encoded by mecA) with a low affinity for b-lactam antibiotics. Recently, a novel variant ...
    • Old drugs to treat resistant bugs: methicillin-resistant Staphylococcus aureus isolates with mecC are susceptible to a combination of penicillin and clavulanic acid 

      Ba, Xiaoliang; Harrison, Ewan M.; Lovering, Andrew L.; Gleadall, Nicholas; Zadoks, Ruth; Parkhill, Julian; Peacock, Sharon J. et al. (American Society for Microbiology, 2015-09-21)
      β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) is mediated by the expression of an alternative penicillin-binding protein 2a (PBP2a, encoded by mecA) with a low affinity for β-lactam antibiotics. ...
    • Systematic surveillance detects multiple silent introductions and household transmission of methicillin-resistant Staphylococcus aureus USA300 in the east of England 

      Toleman, Michelle S.; Reuter, Sandra; Coll, Francesc; Harrison, Ewan M.; Blane, Beth; Brown, Nicholas M.; Török, M. Estée et al. (Oxford University Press, 2016-04-27)
      Background. The spread of USA300 methicillin-resistant Staphylococcus aureus (MRSA) across the United States (US) resulted in an epidemic of infections. In Europe, only sporadic cases or small clusters of USA300 infections ...
    • The use of genome wide association methods to investigate pathogenicity, population structure and serovar in Haemophilus parasuis 

      Howell, Kate J.; Weinert, Lucy A.; Chaudhuri, Roy R.; Luan, Shi-Lu; Peters, Sarah E.; Corander, Jukka; Harris, David et al. (BioMed Central, 2014-12-24)
      Background: Haemophilus parasuis is the etiologic agent of Glässer’s disease in pigs and causes devastating losses to the farming industry. Whilst some hyper-virulent isolates have been described, the relationship between ...
    • Whole genome investigation of a divergent clade of the pathogen Streptococcus suis 

      Baig, Abiyad; Weinert, Lucy A.; Peters, Sarah E.; Howell, Kate J.; Chaudhuri, Roy R.; Wang, Jinhong; Holden, Matthew T. G. et al. (Frontiers, 2015-11-04)
      Streptococcus suis is a major porcine and zoonotic pathogen responsible for significant economic losses in the pig industry and an increasing number of human cases. Multiple isolates of S. suis show marked genomic diversity. ...
    • Whole-genome sequencing of multidrug-resistant Mycobacterium tuberculosis isolates from Myanmar 

      Aung, Htin Lin; Moradigaravand, Thanda Tun Danesh; Köser, Claudio U.; Nyunt, Wint Wint; Aung, Si Thu; Lwin, Thandar; Thinn, Kyi Kyi et al. (Elsevier, 2016)
      SETTING AND OBJECTIVES. Drug-resistant tuberculosis (TB) is a major health threat in Myanmar. We conducted an initial study to explore the potential utility of whole-genome sequencing (WGS) for the diagnosis and management ...
    • Whole-genome sequencing reveals transmission of vancomycin-resistant Enterococcus faecium in a healthcare network 

      Brodrick, Hayley J.; Raven, Kathy E.; Harrison, Ewan M.; Blane, Beth; Reuter, Sandra; Török, M. Estée; Parkhill, Julian et al. (BioMed Central, 2016-01-12)
      Background: Bacterial whole-genome sequencing (WGS) has the potential to identify reservoirs of multidrug-resistant organisms and transmission of these pathogens across healthcare networks. We used WGS to define transmission ...