Now showing items 1-15 of 15

    • Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study 

      Brunner, Clair; Davies, Neil M; Martin, Richard M; Eeles, Rosalind; Easton, Doug; Kote-Jarai, Zsofia; Amin, Al Olama Ali et al. (Wiley, 2016-09-19)
      Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ...
    • Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels 

      Bonilla, Carolina; Lewis, Sarah J; Rowlands, Mari-Anne; Gaunt, Tom R; Smith, George Davey; Gunnell, David; Palmer, Tom et al. (2016)
    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 

      Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb; Pomerantz, Mark; Li, Fugen; Long, Henry W; Ingles, Sue A et al. (Nature Publishing Group, 2016-04-07)
      Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...
    • Blood lipids and prostate cancer: a Mendelian randomization analysis 

      Bull, Caroline J; Bonilla, Carolina; Holly, Jeff MP; Perks, Claire M; Davies, Neil; Haycock, Philip; Yu, Oriana Hoi Yun et al. (2016-03-19)
    • Development and validation of risk score for predicting positive repeat prostate biopsy in patients with a previous negative biopsy in a UK population 

      Rochester, Mark A; Pashayan, Nora; Matthews, Fiona E; Doble, Andrew; McLoughlin, John (2009-07-16)
      Abstract Background Little evidence is available to determine which patients should undergo repeat biopsy after initial benign extended core biopsy (ECB). Attempts have been made to reduce the frequency of negative repeat ...
    • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types 

      Kar, Siddhartha P; Beesley, Jonathan; Amin, Al Olama Ali; Michailidou, Kyriaki; Tyrer, Jonathan; Kote-Jarai, ZSofia; Lawrenson, Kate et al. (American Association for Cancer Research, 2016-07-17)
      Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest ...
    • Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. 

      Lophatananon, Artitaya; Stewart-Brown, Sarah; Kote-Jarai, Zsofia; Olama, Seyed Ali; Garcia, Sara Benlloch; Neal, David E; Hamdy, Freddie C et al. (2017-08)
    • Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis 

      Pashayan, Nora; Duffy, Stephen W; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Martin, Richard M; Harrington, Patricia et al. (Nature Publishing Group, 2015-01-08)
      Purpose: This study aimed to quantify the probability of overdiagnosis of prostate cancer by polygenic risk. Methods: We calculated the polygenic risk score based on 66 known prostate cancer susceptibility variants for ...
    • Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis 

      Taylor, Amy E; Martin, Richard M; Geybels, Milan S; Stanford, Janet L; Shui, Irene; Eeles, Rosalind; Easton, Doug et al. (2016-10-26)
    • Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. 

      Khankari, Nikhil K; Murff, Harvey J; Zeng, Chenjie; Wen, Wanqing; Eeles, Rosalind A; Easton, Douglas Frederick; Kote-Jarai, Zsofia et al. (2016-08-04)
    • Population-based precision cancer screening: a symposium on evidence, epidemiology, and next steps 

      Marcus, Pamela M; Pashayan, Nora; Church, Timothy R; Doria-Rose, V Paul; Gould, Michael K; Hubbard, Rebecca A; Marrone, Michael et al. (2016-08-09)
    • Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort 

      Bonilla, Carolina; Lewis, Sarah J; Martin, Richard M; Donovan, Jenny L; Hamdy, Freddie C; Neal, David E; Eeles, Rosalind et al. (2016-04-04)
    • Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci 

      Amin, Al Olama Ali; Benlloch, Sara; Antoniou, Antonis; Giles, Graham G; Severi, Gianluca; Neal, David; Hamdy, Freddie C et al. (AACR, 2015-04-02)
      BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk. These variants can be used ...
    • SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns. 

      Lin, Hui-Yi; Chen, Dung-Tsa; Huang, Po-Yu; Liu, Yung-Hsin; Ochoa, Augusto; Zabaleta, Jovanny; Mercante, Donald E et al. (Oxford University Press, 2017-03)
      $\textbf{MOTIVATION}$: Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped. ...