Now showing items 7-17 of 17

    • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types 

      Kar, Siddhartha P; Beesley, Jonathan; Amin, Al Olama Ali; Michailidou, Kyriaki; Tyrer, Jonathan; Kote-Jarai, ZSofia; Lawrenson, Kate et al. (American Association for Cancer Research, 2016-07-17)
      Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest ...
    • Height, selected genetic markers and prostate cancer risk: results from the PRACTICAL consortium. 

      Lophatananon, Artitaya; Stewart-Brown, Sarah; Kote-Jarai, Zsofia; Olama, Seyed Ali; Garcia, Sara Benlloch; Neal, David E; Hamdy, Freddie C et al. (Springer Nature, 2017-08)
      BACKGROUND: Evidence on height and prostate cancer risk is mixed, however, recent studies with large data sets support a possible role for its association with the risk of aggressive prostate cancer. METHODS: We analysed ...
    • Implications of polygenic risk-stratified screening for prostate cancer on overdiagnosis 

      Pashayan, Nora; Duffy, Stephen W; Neal, David E; Hamdy, Freddie C; Donovan, Jenny L; Martin, Richard M; Harrington, Patricia et al. (Nature Publishing Group, 2015-01-08)
      Purpose: This study aimed to quantify the probability of overdiagnosis of prostate cancer by polygenic risk. Methods: We calculated the polygenic risk score based on 66 known prostate cancer susceptibility variants for ...
    • Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis 

      Taylor, Amy E; Martin, Richard M; Geybels, Milan S; Stanford, Janet L; Shui, Irene; Eeles, Rosalind; Easton, Doug et al. (Wiley, 2016-10-26)
      Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian ...
    • Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. 

      Seibert, Tyler M; Fan, Chun Chieh; Wang, Yunpeng; Zuber, Verena; Karunamuni, Roshan; Parsons, J Kellogg; Eeles, Rosalind A et al. (BMJ, 2018-01-10)
      Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines ...
    • Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. 

      Khankari, Nikhil K; Murff, Harvey J; Zeng, Chenjie; Wen, Wanqing; Eeles, Rosalind A; Easton, Douglas Frederick; Kote-Jarai, Zsofia et al. (2016-08-04)
    • Population-based precision cancer screening: a symposium on evidence, epidemiology, and next steps 

      Marcus, Pamela M; Pashayan, Nora; Church, Timothy R; Doria-Rose, V Paul; Gould, Michael K; Hubbard, Rebecca A; Marrone, Michael et al. (American Association for Cancer Research, 2016-08-09)
    • Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort 

      Bonilla, Carolina; Lewis, Sarah J; Martin, Richard M; Donovan, Jenny L; Hamdy, Freddie C; Neal, David E; Eeles, Rosalind et al. (BioMed Central, 2016-04-04)
      Background: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates ...
    • Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci 

      Amin, Al Olama Ali; Benlloch, Sara; Antoniou, Antonis; Giles, Graham G; Severi, Gianluca; Neal, David; Hamdy, Freddie C et al. (AACR, 2015-04-02)
      BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk. These variants can be used ...
    • SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns. 

      Lin, Hui-Yi; Chen, Dung-Tsa; Huang, Po-Yu; Liu, Yung-Hsin; Ochoa, Augusto; Zabaleta, Jovanny; Mercante, Donald E et al. (Oxford University Press, 2017-03)
      $\textbf{MOTIVATION}$: Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped. ...
    • Validation of loci at 2q14.2 and 15q21.3 as risk factors for testicular cancer. 

      Loveday, Chey; Litchfield, Kevin; Levy, Max; Holroyd, Amy; Broderick, Peter; Kote-Jarai, Zsofia; Dunning, Alison Margaret et al. (Impact Journals, 2018-02)
      Testicular germ cell tumor (TGCT), the most common cancer in men aged 18 to 45 years, has a strong heritable basis. Genome-wide association studies (GWAS) have proposed single nucleotide polymorphisms (SNPs) at a number ...