Now showing items 1-11 of 11

    • Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases 

      Smyth, Deborah J; Howson, Joanna McCammond; Payne, Felicity; Maier, Lisa M; Bailey, Rebecca; Holland, Kieran; Lowe, Christopher Eric et al. (2006-03-06)
    • The candidate genes TAF5L, TCF7, PDCD1, IL6 and ICAM1 cannot be excluded from having effects in type 1 diabetes 

      Cooper, Jason David; Smyth, Deborah J; Bailey, Rebecca; Payne, Felicity; Downes, Kate; Godfrey, Lisa M; Masters, Jennifer et al. (2007-11-28)
    • Construction and analysis of tag single nucleotide polymorphism maps for six human-mouse orthologous candidate genes in type 1 diabetes 

      Maier, Lisa M; Smyth, Deborah J; Vella, Adrian; Payne, Felicity; Cooper, Jason David; Pask, Rebecca; Lowe, Christopher E et al. (2005-02-18)
    • Development of an integrated genome informatics, data management and workflow infrastructure: A toolbox for the study of complex disease genetics 

      Burren, Oliver S; Healy, Barry C; Lam, Alex C; Schuilenburg, Helen; Dolman, Geoffrey E; Everett, Vincent H; Laneri, Davide et al. (2004-01-01)
    • Hypoinsulinaemic, hypoketotic hypoglycaemia due to mosaic genetic activation of PI3-kinase. 

      Leiter, Sarah M; Parker, Victoria ER; Welters, Alena; Knox, Rachel; Rocha, Nuno; Clark, Graeme Richard; Payne, Felicity et al. (2017-08)
      OBJECTIVE: Genetic activation of the insulin signal-transducing kinase AKT2 causes syndromic hypoketotic hypoglycaemia without elevated insulin. Mosaic activating mutations in class 1A phospatidylinositol-3-kinase (PI3K), ...
    • Hypomorphism for human NSMCE2/MMS21 causes primordial dwarfism and insulin resistance 

      Payne, Felicity; Colnaghi, Rita; Rocha, Nuno; Seth, Asha; Harris, Julie; Carpenter, Gillian; Bottomley, William E et al. (American Society for Clinical Investigation, 2014-09-02)
    • Insulin resistance uncoupled from dyslipidemia due to C-terminal PIK3R1 mutations 

      Huang-Doran, Isabel; Tomlinson, Patsy; Payne, Felicity; Gast, Alexandra; Sleigh, Alison; Bottomley, William; Harris, Julie et al. (American Society for Clinical Investigation, 2016-10-05)
    • Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance. 

      Lotta, Luca Andrea; Gulati, Pawan; Day, Felix Ranulf; Payne, Felicity; Ongen, Halit; van, de Bunt Martijn; Gaulton, Kyle J et al. (Nature Publishing Group, Nature Publishing Group, 2017-01)
      Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the mechanisms underlying this link remain obscure. Using an integrative genomic approach, we identify 53 genomic regions associated with ...
    • Polymorphism discovery and association analyses of the interferon genes in type 1 diabetes 

      Morris, Gerard AJ; Lowe, Christopher Eric; Cooper, Jason David; Payne, Felicity; Vella, Adrian; Godfrey, Lisa M; Hulme, John S et al. (2006-02-22)
    • Sequencing and association analysis of the type 1 diabetes - linked region on chromosome 10p12-q11. 

      Nejentsev, Sergey; Smink, Luc J; Smyth, Deborah J; Bailey, Rebecca; Lowe, Christopher Eric; Payne, Felicity; Masters, Jennifer et al. (2007-05-17)
      Background: In an effort to locate susceptibility genes for type I diabetes (TID) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in a combined ...
    • Truncation of POC1A associated with short stature and extreme insulin resistance 

      Chen, Jian-Hua; Segni, Maria; Payne, Felicity; Huang-Doran, Isabel; Sleigh, Alison; Adams, Claire Louise; UK10K, Frances Lucy et al. (Bioscientifica, 2015-10-01)