Now showing items 1-5 of 5

    • Further developments towards a genome-scale metabolic model of yeast 

      Dobson, Paul D.; Smallbone, Kieran; Jameson, Daniel; Simeonidis, Evangelos; Lanthaler, Karin; Pir, Pinar; Lu, Chuan et al. (2010-10-28)
      Abstract Background To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven ...
    • Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. 

      Lanthaler, Karin; Bilsland, Elizabeth; Dobson, Paul D.; Moss, Harry J.; Pir, Pinar; Kell, Douglas B.; Oliver, Stephen G. (2011-10-24)
      Abstract Background The uptake of drugs into cells has traditionally been considered to be predominantly via passive diffusion through the bilayer portion of the cell membrane. The recent recognition that drug uptake is ...
    • Haploinsufficiency and the sex chromosomes from yeasts to humans 

      de Clare, Michaela; Pir, Pinar; Oliver, Stephen G (2011-02-28)
      Abstract Background Haploinsufficient (HI) genes are those for which a reduction in copy number in a diploid from two to one results in significantly reduced fitness. Haploinsufficiency is increasingly implicated in human ...
    • How yeast re-programmes its transcriptional profile in response to different nutrient impulses 

      Dikicioglu, Duygu; Karabekmez, Erkan; Rash, Bharat; Pir, Pinar; Kirdar, Betul; Oliver, Stephen G (2011-09-25)
      Abstract Background A microorganism is able to adapt to changes in its physicochemical or nutritional environment and this is crucial for its survival. The yeast, Saccharomyces cerevisiae, has developed mechanisms to respond ...
    • The genetic control of growth rate: a systems biology study in yeast. 

      Pir, Pinar; Gutteridge, Alex; Wu, Jian; Rash, Bharat; Kell, Douglas B; Zhang, Nianshu; Oliver, Stephen G (2012-01-13)
      Abstract Background Control of growth rate is mediated by tight regulation mechanisms in all free-living organisms since long-term survival depends on adaptation to diverse environmental conditions. The yeast, Saccharomyces ...