Now showing items 1-2 of 2

    • Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. 

      Barbieri, Isaia; Tzelepis, Konstantinos; Pandolfini, Luca; Shi, Junwei; Millán-Zambrano, Gonzalo; Robson, Samuel C; Aspris, Demetrios et al. (Springer Nature, 2017-12)
      N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding and non-coding RNAs, catalysed by the METTL3/METTL14 methyltransferase complex. Here we define a novel pathway specific for METTL3, implicated ...
    • Relationship between the tissue-specificity of mouse gene expression and the evolutionary origin and function of the proteins 

      Freilich, Shiri; Massingham, Tim; Bhattacharyya, Sumit; Ponstingl, Hannes; Lyons, Paul Anthony; Freeman, Tom C; Thornton, Janet M (2005-06-29)
      Abstract Background The combination of complete genome sequence information with expression data enables us to characterize the relationship between a protein's evolutionary origin or functional category and its expression ...