Now showing items 2-10 of 10

    • Cancer stem cell markers in breast cancer: pathological, clinical and prognostic significance 

      Ali, Hamid R.; Dawson, Sarah-Jane; Blows, Fiona M.; Provenzano, Elena; Pharoah, Paul D. P.; Caldas, Carlos (2011-11-23)
      Abstract Introduction The cancer stem cell (CSC) hypothesis states that tumours consist of a cellular hierarchy with CSCs at the apex driving tumour recurrence and metastasis. Hence, CSCs are potentially of profound clinical ...
    • Computational pathology of pre-treatment biopsies identifies lymphocyte density as a predictor of response to neoadjuvant chemotherapy in breast cancer 

      Ali, H. Raza; Dariush, Aliakbar; Provenzano, Elena; Bardwell, Helen; Abraham, Jean; Iddawela, Mahesh; Vallier, Anne-Laure et al. (BioMed Central, 2016)
      There is a need to improve prediction of response to chemotherapy in breast cancer in order to improve clinical management and this may be achieved by harnessing computational metrics of tissue pathology. We investigated ...
    • Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer 

      Candido do Reis, Francisco J.; Lynn, Stuart; Ali, H. Raza; Eccles, Diana; Hanby, Andrew; Provenzano, Elena; Caldas, Carlos et al. (Elsevier, 2015-05-09)
      Background Citizen science, scientific research conducted by non-specialists, has the potential to facilitate biomedical research using available large-scale data, however validating the results is challenging. The Cell ...
    • Decline in antigenicity of tumour markers by storage time using pathology sections cut from tissue micro-arrays 

      Blows, Fiona M.; Ali, H. Raza; Dawson, Sarah-Jane; Le Quesne, John; Provenzano, Elena; Caldas, Carlos; Pharoah, Paul D. P. (Lippincott Williams & Wilkins/Wolters Kluwer Health, 2015-06-05)
      Sectioning a whole tissue microarrray (TMA block) and storing the sections maximises the number of sections obtained, but may impair the antigenicity of the stored sections. We have investigated the impact of TMA section ...
    • Familial relative risks for breast cancer by pathological subtype: a population-based cohort study 

      Mavaddat, Nasim; Pharoah, Paul D. P.; Blows, Fiona; Driver, Kristy E.; Provenzano, Elena; Thompson, Deborah J.; MacInnis, Robert J. et al. (2010-02-10)
      Abstract Introduction The risk of breast cancer to first degree relatives of breast cancer patients is approximately twice that of the general population. Breast cancer, however, is a heterogeneous disease and it is plausible ...
    • Multifocal clonal evolution characterized using circulating tumor DNA in a case of metastatic breast cancer 

      Murtaza, Muhammed; Dawson, Sarah-­Jane; Pogrebniak, Katherine; Rueda, Oscar M.; Provenzano, Elena; Grant, John; Chin, Suet-Feung et al. (Nature Publishing Group, 2015-11-04)
      Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ...
    • Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium 

      Howat, William; Blows, Fiona; Provenzano, Elena; Brook, Mark; Morris, Lorna; Gazinska, Patrycja; Johnson, Nicola et al. (Wiley, 2014-12-04)
      Breast cancer risk factors and clinical outcomes vary by tumor marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need ...
    • Research data supporting "Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer" 

      Candido do Reis, Francisco J.; Lynn, Stuart; Ali, H. Raza; Eccles, Diana; Hanby, Andrew; Provenzano, Elena; Caldas, Carlos et al. (2015-05-08)
    • The somatic mutation profiles of 2500 primary breast cancers refine their genomic landscapes 

      Pereira, Bernard; Chin, Suet-Feung; Rueda, Oscar M.; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A.; Pugh, Michelle et al. (Nature Publishing Group, 2016)
      The somatic mutation landscape in breast cancer is complex, and inter- and intra-tumour genomic heterogeneity are important clinical challenges. We performed targeted resequencing of 173 breast cancer-related genes in ...