Now showing items 7-10 of 10

    • Multifocal clonal evolution characterized using circulating tumor DNA in a case of metastatic breast cancer 

      Murtaza, Muhammed; Dawson, Sarah-­Jane; Pogrebniak, Katherine; Rueda, Oscar M.; Provenzano, Elena; Grant, John; Chin, Suet-Feung et al. (Nature Publishing Group, 2015-11-04)
      Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ...
    • Performance of automated scoring of ER, PR, HER2, CK5/6 and EGFR in breast cancer tissue microarrays in the Breast Cancer Association Consortium 

      Howat, William; Blows, Fiona; Provenzano, Elena; Brook, Mark; Morris, Lorna; Gazinska, Patrycja; Johnson, Nicola et al. (Wiley, 2014)
      Breast cancer risk factors and clinical outcomes vary by tumor marker expression. However, individual studies often lack the power required to assess these relationships, and large-scale analyses are limited by the need ...
    • Research data supporting "Crowdsourcing the General Public for Large Scale Molecular Pathology Studies in Cancer" 

      Candido do Reis, Francisco J.; Lynn, Stuart; Ali, H. Raza; Eccles, Diana; Hanby, Andrew; Provenzano, Elena; Caldas, Carlos et al. (2015-05-08)
    • The somatic mutation profiles of 2500 primary breast cancers refine their genomic landscapes 

      Pereira, Bernard; Chin, Suet-Feung; Rueda, Oscar M.; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A.; Pugh, Michelle et al. (Nature Publishing Group, 2016)
      The somatic mutation landscape in breast cancer is complex, and inter- and intra-tumour genomic heterogeneity are important clinical challenges. We performed targeted resequencing of 173 breast cancer-related genes in ...