Now showing items 5-10 of 10

    • Identification of six new susceptibility loci for invasive epithelial ovarian cancer 

      Kuchenbaecker, Karoline Bernhardine; Ramus, Susan J; Tyrer, Jonathan; Lee, Andrew; Shen, Howard C; Beesley, Jonathan; Lawrenson, Kate et al. (2015-01-12)
      Genome-wide association studies (GWAS) have identified 12 epithelial ovarian cancer (EOC) susceptibility alleles. The pattern of association at these loci is consistent in BRCA1 and BRCA2 mutation carriers who are at high ...
    • Meta-analysis of 8q24 for seven cancers reveals a locus between NOV and ENPP2 associated with cancer development 

      Brisbin, Abra G; Asmann, Yan W; Song, Honglin; Tsai, Ya-Yu; Aakre, Jeremiah A; Yang, Ping; Jenkins, Robert B et al. (2011-12-05)
      Abstract Background Human chromosomal region 8q24 contains several genes which could be functionally related to cancer, including the proto-oncogene c-MYC. However, the abundance of associations around 128 Mb on chromosome ...
    • The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers 

      Amos, Christopher I; Dennis, Joe; Wang, Zhaoming; Byun, Jinyoung; Schumacher, Fredrick R; Gayther, Simon A; Casey, Graham et al. (American Association for Cancer Research, 2016-10-03)
      Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS 

      Southey, Melissa C; Goldgar, David; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc Derek; Foulkes, William et al. (BMJ Publishing Group, 2016-09-05)
      Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
    • Quantifying the Genetic Correlation between Multiple Cancer Types. 

      Lindström, Sara; Finucane, Hilary; Bulik-Sullivan, Brendan; Schumacher, Fredrick R; Amos, Christopher I; Hung, Rayjean J; Rand, Kristin et al. (2017-09)
    • SNP interaction pattern identifier (SIPI): an intensive search for SNP-SNP interaction patterns. 

      Lin, Hui-Yi; Chen, Dung-Tsa; Huang, Po-Yu; Liu, Yung-Hsin; Ochoa, Augusto; Zabaleta, Jovanny; Mercante, Donald E et al. (Oxford University Press, 2017-03)
      $\textbf{MOTIVATION}$: Testing SNP-SNP interactions is considered as a key for overcoming bottlenecks of genetic association studies. However, related statistical methods for testing SNP-SNP interactions are underdeveloped. ...