Now showing items 3-6 of 6

    • Latency-Associated Viral Interleukin-10 (IL-10) Encoded by Human Cytomegalovirus Modulates Cellular IL-10 and CCL8 Secretion during Latent Infection through Changes in the Cellular MicroRNA hsa-miR-92a 

      Poole, Emma; Avdic, Selmir; Hodkinson, Jemima; Jackson, Sarah; Wills, Mark; Slobedman, Barry; Sinclair, John (American Society for Microbiology, 2014-09-24)
      The UL111A gene of human cytomegalovirus encodes a viral homologue of the cellular immunomodulatory cytokine interleukin 10 (cIL-10), which, due to alternative splicing, results in expression of two isoforms designated ...
    • Latent infection of myeloid progenitors by human cytomegalovirus protects cells from FAS-mediated apoptosis through the cellular IL-10/PEA15 pathway 

      Poole, Emma; Lau, Jonathan; Sinclair, John (Society for General Microbiology, 2015-05-08)
      Latent infection of primary CD34+ progenitor cells by human cytomegalovirus (HCMV) results in their increased survival in the face of pro-apoptotic signals. For instance, we have previously shown that primary myeloid cells ...
    • Report from the Second Cytomegalovirus and Immunosenescence Workshop 

      Wills, Mark; Akbar, Arne; Beswick, Mark; Bosch, Jos A.; Caruso, Calogero; Colonna-Romano, Giuseppina; Dutta, Ambarish et al. (2011-10-28)
      Abstract The Second International Workshop on CMV & Immunosenescence was held in Cambridge, UK, 2-4th December, 2010. The presentations covered four separate sessions: cytomegalovirus and T cell phenotypes; T cell memory ...
    • Sleepless latency of human cytomegalovirus 

      Poole, Emma; Sinclair, John (Springer, 2015-03-14)
      As with all human herpesviruses, human cytomegalovirus (HCMV) persists for the lifetime of the host by establishing a latent infection, which is broken by periodic reactivation events. One site of HCMV latency is in the ...